DegronMD

Uniprot ID: P16435

Source protein: NADPH--cytochrome P450 reductase

Source gene: POR

Class: DEG_SPOP_SBC_1

Location: 6:10

E3 ligase: SPOP

DEGRON score: 0.7465

ASA_SCORE: 81.18

COIL: 0.8936

CONS_SCORE: 0.2457

DSS_SCORE: 0.5558

HELIX: 0.065

FCONS_SCORE: 0.9651

RIG_SCORE: 0.7119

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D10G	TCGA-A5-A0G1	UCEC	TCGA	VDTSS	DEG_SPOP_SBC_1	0.7198
p.D10G	DO42472	UCEC	ICGC	VDTSS	DEG_SPOP_SBC_1	0.7198
p.A20V	TCGA-FS-A4F0	SKCM	TCGA	VDTSS	DEG_SPOP_SBC_1	0.0556
p.A20V	DO37891	SKCM	ICGC	VDTSS	DEG_SPOP_SBC_1	0.0556
p.S16F	DO49763	BLCA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1667
p.R4G	DO5829	BRCA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.R10K	DO5326	BRCA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.7237
p.C9F	DO229025	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.7108
p.H8Y	DO222395	MELA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.7229
p.R4W	DO222536	MELA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.T11I	DO50707	ORCA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.3056
p.G12E	DO46657	PAAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.V17A	DO46657	PAAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1389
p.R4L	DO38356	STAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.V9M	SIDM00855	Other Sarcomas	GDSC	VDTSS	DEG_SPOP_SBC_1	0.7208
p.V9M	ACH-000375	Kidney Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.7208
p.M4T	ACH-000807	Brain Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.2778
p.A7V	ACH-002256	Leukemia	CCLE	VDTSS	DEG_SPOP_SBC_1	0.6936
p.G2E	MZ7-mel	skin	COSMIC	VDTSS	DEG_SPOP_SBC_1	0.2222
p.Q13R	HT-3	cervix	COSMIC	VDTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9909	More...
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.9544	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2313:2317	VDTSS	SPOP	0.5257	More...
P16435	NADPH--cytochrome P450 reductase	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.7465	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2527:2531	VDTSS	SPOP	0.9726	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9888	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1985:1989	VDTSS	SPOP	0.9585	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	713:717	VDTSS	SPOP	0.8379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons