DegronMD - P16435(POR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D10G	TCGA-A5-A0G1	UCEC	TCGA	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7198
p.D10G	DO42472	UCEC	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7198
p.A20V	TCGA-FS-A4F0	SKCM	TCGA	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.0556
p.A20V	DO37891	SKCM	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.0556
p.S16F	DO49763	BLCA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1667
p.R4G	DO5829	BRCA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.R10K	DO5326	BRCA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7237
p.C9F	DO229025	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7108
p.H8Y	DO222395	MELA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7229
p.R4W	DO222536	MELA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.T11I	DO50707	ORCA	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.3056
p.G12E	DO46657	PAAD	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.V17A	DO46657	PAAD	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1389
p.R4L	DO38356	STAD	ICGC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.V9M	SIDM00855	Other Sarcomas	GDSC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7208
p.V9M	ACH-000375	Kidney Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7208
p.M4T	ACH-000807	Brain Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.A7V	ACH-002256	Leukemia	CCLE	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.6936
p.G2E	MZ7-mel	skin	COSMIC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2222
p.Q13R	HT-3	cervix	COSMIC	VDTSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.25

Kaplan plot for POR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POR

UniProt ID: P16435

Entrez ID: 5447

Protein name: NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POR in