DegronMD - O95359(TACC2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S408F	TCGA-13-0920	OV	TCGA	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.3056
p.S408F	DO28099	OV	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.3056
p.W923C	TCGA-13-2061	OV	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1667
p.W923C	DO27970	OV	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1667
p.S2248A	TCGA-19-1386	GBM	TCGA	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation altering degron motif	0.7588
p.A943V	TCGA-2A-A8W3	PRAD	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.5825
p.A943V	DO51309	PRAD	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.5825
p.T1955N	TCGA-2G-AAKH	TGCT	TCGA	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation rewiring degron network	0.3056
p.P1998H	TCGA-55-6971	LUAD	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation altering degron motif	0.6583
p.G2251R	TCGA-55-8094	LUAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.3056
p.G2251R	SIDM01187	Breast Carcinoma	GDSC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.3056
p.Q904E	TCGA-55-8204	LUAD	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1667
p.Q904E	DO45322	LUAD	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1667
p.P2513L	TCGA-78-8662	LUAD	TCGA	DYR	CBL_MET	2518:2520	Mutation rewiring degron network	0.1944
p.G1991V	TCGA-86-8073	LUAD	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.25
p.I2525V	TCGA-A3-3313	KIRC	TCGA	DYR	CBL_MET	2518:2520	Mutation rewiring degron network	0.1944
p.E930Q	TCGA-A8-A09G	BRCA	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.1389
p.E930Q	DO1990	BRCA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.1389
p.P727H	TCGA-AA-3977	COAD	TCGA	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.7694
p.P727H	TCGA-AA-3977	COAD	TCGA	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7694
p.P727H	DO8730	COAD	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.7694
p.P727H	DO8730	COAD	ICGC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7694
p.L693S	TCGA-AG-3891	READ	TCGA	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.0556
p.L693S	DO36388	READ	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.0556
p.E2526G	TCGA-AJ-A3EL	UCEC	TCGA	DYR	CBL_MET	2518:2520	Mutation rewiring degron network	0.1667
p.P1969S	TCGA-AP-A5FX	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation rewiring degron network	0.0833
p.A423T	TCGA-AX-A0J1	UCEC	TCGA	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1111
p.A423T	DO41199	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1111
p.S926Y	TCGA-B5-A11E	UCEC	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.0833
p.S926Y	DO41644	UCEC	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.0833
p.P431H	TCGA-B5-A3FC	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1667
p.P431H	DO41871	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1667
p.I2462M	TCGA-BA-5152	HNSC	TCGA	PTPAAT	DEG_SCF_FBW7_1	2450:2455	Mutation rewiring degron network	0.1389
p.P2247T	TCGA-BF-A1Q0	SKCM	TCGA	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation altering degron motif	0.7031
p.P2247T	TCGA-EE-A17Z	SKCM	TCGA	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation altering degron motif	0.7031
p.P2247T	TCGA-EE-A2GO	SKCM	TCGA	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation altering degron motif	0.7031
p.S2351F	TCGA-BF-AAP7	SKCM	TCGA	PFSST	DEG_SPOP_SBC_1	2349:2353	Mutation altering degron motif	0.7982
p.K940T	TCGA-BR-4280	STAD	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.6195
p.K940T	DO38663	STAD	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.6195
p.P402S	TCGA-BS-A0UF	UCEC	TCGA	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1389
p.P402S	DO41488	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1389
p.G2243E	TCGA-CV-A6K2	HNSC	TCGA	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.2778
p.P1970Q	TCGA-D3-A2JK	SKCM	TCGA	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation rewiring degron network	0.0556
p.E946K	TCGA-D3-A8GL	SKCM	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.3056
p.E946K	DO220868	MELA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.3056
p.E946K	DO50287	SKCM	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.3056
p.P2000T	TCGA-D3-A8GN	SKCM	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation altering degron motif	0.7031
p.P1987L	TCGA-D8-A27K	BRCA	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.1389
p.Q904H	TCGA-DD-A4NH	LIHC	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1667
p.Q904H	DO44907	LIHC	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1667
p.K2355I	TCGA-DU-6407	LGG	TCGA	PFSST	DEG_SPOP_SBC_1	2349:2353	Mutation rewiring degron network	0.2778
p.A416T	TCGA-EA-A410	CESC	TCGA	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.3056
p.A416T	DO49929	CESC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.3056
p.G2002D	TCGA-EB-A41A	SKCM	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation altering degron motif	0.7198
p.G2002D	TCGA-FW-A3TV	SKCM	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation altering degron motif	0.7198
p.P918T	TCGA-EE-A2MG	SKCM	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.3056
p.P918T	DO37421	SKCM	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.3056
p.S712Y	TCGA-EO-A22X	UCEC	TCGA	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation blocking phosphorylation signal	0.75
p.S712Y	DO43907	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation blocking phosphorylation signal	0.75
p.E2515D	TCGA-ER-A19H	SKCM	TCGA	DYR	CBL_MET	2518:2520	Mutation rewiring degron network	0.25
p.G954S	TCGA-F4-6570	COAD	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.0833
p.G954S	DO10443	COAD	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.0833
p.E1951D	TCGA-FI-A2D5	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation rewiring degron network	0.1944
p.V1999A	TCGA-FI-A2D5	UCEC	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation altering degron motif	0.6936
p.G908S	TCGA-FS-A1ZZ	SKCM	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.2778
p.G908S	DO37412	SKCM	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.2778
p.E950K	TCGA-G2-A2ES	BLCA	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.1944
p.E950K	DO785	BLCA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.1944
p.K447N	TCGA-G4-6586	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation substituting flanking lysine	0.2778
p.K447N	DO9698	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation substituting flanking lysine	0.2778
p.P2452T	TCGA-GN-A262	SKCM	TCGA	PTPAAT	DEG_SCF_FBW7_1	2450:2455	Mutation altering degron motif	0.7031
p.T2246A	TCGA-HU-8602	STAD	TCGA	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation altering degron motif	0.825
p.K2509N	TCGA-HU-A4GH	STAD	TCGA	DYR	CBL_MET	2518:2520	Mutation substituting flanking lysine	0.1944
p.S441T	TCGA-IN-A6RL	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation altering degron motif	0.6005
p.S441T	DO51738	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation altering degron motif	0.6005
p.F2013S	TCGA-JX-A3Q0	CESC	TCGA	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.0556
p.F2350V	TCGA-KK-A8I6	PRAD	TCGA	PFSST	DEG_SPOP_SBC_1	2349:2353	Mutation altering degron motif	0.5957
p.S925I	TCGA-KK-A8IG	PRAD	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1111
p.S925I	DO219331	PRAD	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1111
p.R709I	TCGA-N8-A4PM	UCS	TCGA	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.6991
p.P724L	TCGA-NI-A8LF	LIHC	TCGA	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.6471
p.P724L	DO49715	LIHC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.6471
p.Q702P	TCGA-P3-A6SX	HNSC	TCGA	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.3056
p.Q702P	DO49051	HNSC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.3056
p.E2526K	TCGA-W3-A825	SKCM	TCGA	DYR	CBL_MET	2518:2520	Mutation rewiring degron network	0.1667
p.E929V	TCGA-XY-A8S2	TGCT	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.1111
p.H741Y	DO1954	BRCA	ICGC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.1389
p.L910M	DO229389	BTCA	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation altering degron motif	0.5999
p.L2254R	DO7776	COAD	ICGC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.2222
p.R442S	DO8730	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.3056
p.G714D	DO219889	DLBC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.25
p.G714D	DO219889	DLBC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.0556
p.G714D	DO49046	HNSC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.25
p.G714D	DO49046	HNSC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.0556
p.G714D	DO50973	LICA	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.25
p.G714D	DO50973	LICA	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.0556
p.D450Y	DO223118	ESCA	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.0833
p.R948Q	DO233151	GACA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.25
p.K947R	DO233098	GACA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.2778
p.G399R	DO229505	LAML	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00216	Colorectal Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00064	Hepatocellular Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00411	Pancreatic Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00535	Chondrosarcoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00370	T-Lymphoblastic Leukemia	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00590	Oral Cavity Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00568	Gastric Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00817	Kidney Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00580	Acute Myeloid Leukemia	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM01257	Hepatocellular Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM01033	Bladder Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00531	Pancreatic Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM01770	Gastric Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM01320	Pancreatic Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM00062	Hepatocellular Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G399R	SIDM01442	Glioma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.A2359S	DO229028	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	2349:2353	Mutation blocking phosphorylation signal	0.6111
p.D448Y	DO229027	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.D448Y	DO229031	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.G1957V	DO229006	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation altering degron motif	0.7532
p.L401F	DO229009	LICA	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1111
p.G1946V	DO23624	LUAD	ICGC	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation blocking phosphorylation signal	0.5
p.S2517F	DO26605	LUSC	ICGC	DYR	CBL_MET	2518:2520	Mutation rewiring degron network	0.3056
p.F447I	DO228435	MALY	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation substituting flanking lysine	0.2778
p.D914N	DO220862	MELA	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation altering degron motif	0.6932
p.D914N	DO37839	SKCM	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation altering degron motif	0.6932
p.P942R	DO220871	MELA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.6401
p.S712F	DO220906	MELA	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation blocking phosphorylation signal	0.75
p.S424L	DO222402	MELA	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0833
p.D421N	DO222714	MELA	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1667
p.A719V	DO28119	OV	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1111
p.A719V	DO28119	OV	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.1944
p.A719V	DO28119	OV	ICGC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.1389
p.A719V	DO41235	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1111
p.A719V	DO41235	UCEC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.1944
p.A719V	DO41235	UCEC	ICGC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.1389
p.R2520H	DO228138	PBCA	ICGC	DYR	CBL_MET	2518:2520	Mutation altering degron motif	0.8244
p.G908C	DO232352	PBCA	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.2778
p.F428V	DO219317	PRAD	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.0833
p.G951E	DO219878	SKCA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.1667
p.P724S	DO229459	SKCA	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.6752
p.M2259I	DO218863	SKCA	ICGC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation substituting flanking lysine	0.1944
p.M2259I	DO37410	SKCM	ICGC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation substituting flanking lysine	0.1944
p.S399F	DO37819	SKCM	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.0556
p.G1957D	DO37429	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation altering degron motif	0.7198
p.G1957D	DO38159	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation altering degron motif	0.7198
p.R2010C	DO50299	SKCM	ICGC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.1389
p.P403L	DO48665	SKCM	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1667
p.S429F	DO219472	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1111
p.A1986T	DO51774	STAD	ICGC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.1111
p.S737G	DO51776	STAD	ICGC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.1389
p.S737G	DO51776	STAD	ICGC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.25
p.P403H	DO219787	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1667
p.A409V	DO42105	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation altering degron motif	0.6936
p.S695L	DO41271	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1111
p.L708M	DO41361	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.711
p.K734N	SIDM00373	Endometrial Carcinoma	GDSC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.5806
p.K734N	ACH-000974	Endometrial/Uterine Cancer	CCLE	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.5806
p.A448S	SIDM01169	Ovarian Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM00336	Melanoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM01183	Other Solid Cancers	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM00151	Ovarian Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM00936	Bladder Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM00929	Chondrosarcoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM01766	Chondrosarcoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.A448S	SIDM01726	Ewing's Sarcoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1389
p.S934A	SIDM00336	Melanoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.25
p.S934A	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.25
p.S934A	SIDM01766	Chondrosarcoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.25
p.E435K	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.2778
p.E435K	ACH-000647	Esophageal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.2778
p.E435K	TE-1	oesophagus	COSMIC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.2778
p.P437S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation altering degron motif	0.6752
p.V1392G	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	1392:1396	Mutation altering degron motif	0.7532
p.V1392G	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	1392:1396	Mutation altering degron motif	0.7532
p.E414K	SIDM00589	Oral Cavity Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation altering degron motif	0.591
p.E414K	ACH-000778	Head and Neck Cancer	CCLE	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation altering degron motif	0.591
p.E414K	HSC-3	upper aerodigestive tract	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation altering degron motif	0.591
p.K940R	SIDM01178	Other Solid Cancers	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.6126
p.K940R	SIDM01045	Endometrial Carcinoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.6126
p.G2251W	SIDM01099	Neuroblastoma	GDSC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.3056
p.G2251W	SK-N-FI	autonomic ganglia	COSMIC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.3056
p.R948W	SIDM00060	Ovarian Carcinoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.25
p.R2004W	SIDM00410	Other Blood Cancers	GDSC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.3056
p.R2004W	SIDM01086	B-Lymphoblastic Leukemia	GDSC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.3056
p.R2004W	YT	haematopoietic and lymphoid tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.3056
p.R2004W	RS4-11	haematopoietic and lymphoid tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.3056
p.G706R	SIDM01018	Hodgkin's Lymphoma	GDSC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.6457
p.G706R	ACH-000815	Lymphoma	CCLE	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.6457
p.G706R	KM-H2	haematopoietic and lymphoid tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.6457
p.K2530I	SIDM01611	Endometrial Carcinoma	GDSC	DYR	CBL_MET	2518:2520	Mutation substituting flanking lysine	0.1667
p.M450V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.0833
p.E414D	SIDM01316	Ewing's Sarcoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation altering degron motif	0.5647
p.V731I	ACH-000372	Leukemia	CCLE	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7076
p.V731I	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7076
p.G715D	ACH-000563	Lung Cancer	CCLE	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2222
p.G715D	ACH-000563	Lung Cancer	CCLE	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.0833
p.G715D	ACH-001670	Brain Cancer	CCLE	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2222
p.G715D	ACH-001670	Brain Cancer	CCLE	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.0833
p.G715D	EBC-1	lung	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2222
p.G715D	EBC-1	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.0833
p.G715D	TASK1	bone	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2222
p.G715D	TASK1	bone	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.0833
p.P412L	ACH-000593	Bladder Cancer	CCLE	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation altering degron motif	0.7582
p.K935E	ACH-000702	Lymphoma	CCLE	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.2778
p.K935E	L-1236	haematopoietic and lymphoid tissue	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.2778
p.R2004Q	ACH-000928	Endometrial/Uterine Cancer	CCLE	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.3056
p.A938V	ACH-000994	Endometrial/Uterine Cancer	CCLE	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.6936
p.L701M	ACH-002289	Leukemia	CCLE	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2778
p.L701M	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2778
p.T906A	SNU-1040	large intestine	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.2222
p.K917R	MEL-HO	skin	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation altering degron motif	0.7237
p.R2008W	RS4-11	haematopoietic and lymphoid tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.1944
p.R2008W	YT	haematopoietic and lymphoid tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation rewiring degron network	0.1944
p.L407P	OE21	oesophagus	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.2778
p.L407P	VMRC-RCW	kidney	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.2778
p.L407P	Saos-2	bone	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.2778
p.L407P	MCF7	breast	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.2778
p.G1404D	Farage	haematopoietic and lymphoid tissue	COSMIC	VDTSS	DEG_SPOP_SBC_1	1392:1396	Mutation rewiring degron network	0.1111
p.G727D	TASK1	bone	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.7198
p.G727D	TASK1	bone	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7198
p.G727D	EBC-1	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.7198
p.G727D	EBC-1	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7198
p.E725Q	CAL-148	breast	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.6744
p.H729P	NCI-H2170	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.7694
p.H729P	NCI-H2170	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7694
p.H729P	NCI-H520	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation altering degron motif	0.7694
p.H729P	NCI-H520	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation altering degron motif	0.7694
p.P429L	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1111
p.A940V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation altering degron motif	0.6936
p.V409I	KYSE-50	oesophagus	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation altering degron motif	0.7076
p.H741P	NCI-H2170	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.1389
p.H741P	NCI-H520	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.1389
p.E446Q	NTERA-2_cl_D1	testis	COSMIC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1944
p.L713M	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2778
p.R1959W	YT	haematopoietic and lymphoid tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation altering degron motif	0.8634
p.R1959W	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	1956:1960	Mutation altering degron motif	0.8634
p.K905E	L-1236	haematopoietic and lymphoid tissue	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.1944
p.V2519I	NB-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	2518:2520	Mutation altering degron motif	0.7076
p.N1997K	HOP-92	lung	COSMIC	SETVPVPDGP	DEG_COP1_1	1994:2003	Mutation altering degron motif	0.6918
p.P716L	KYSE-450	oesophagus	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1944
p.P716L	KYSE-450	oesophagus	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	724:730	Mutation rewiring degron network	0.1111
p.P716L	KYSE-450	oesophagus	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.0556
p.E442Q	NTERA-2_cl_D1	testis	COSMIC	PGSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.3056
p.V710I	NB-4	haematopoietic and lymphoid tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.7076
p.P709S	SW684	soft tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.6752
p.K947E	L-1236	haematopoietic and lymphoid tissue	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.2778
p.V743I	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	TPVAEVAPK	DEG_SIAH_1	726:734	Mutation rewiring degron network	0.0833
p.K917E	L-1236	haematopoietic and lymphoid tissue	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation altering degron motif	0.7022
p.E909Q	NTERA-2_cl_D1	testis	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	910:917	Mutation rewiring degron network	0.3056
p.G2255W	SK-N-FI	autonomic ganglia	COSMIC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.1944
p.P2518S	SW684	soft tissue	COSMIC	DYR	CBL_MET	2518:2520	Mutation altering degron motif	0.6752
p.P2525L	KYSE-450	oesophagus	COSMIC	DYR	CBL_MET	2518:2520	Mutation rewiring degron network	0.1944
p.A417V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.2778
p.Q949R	MFE-319	endometrium	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	937:945	Mutation rewiring degron network	0.2222
p.P2238L	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VTPSDS	DEG_SCF_FBW7_1	2245:2250	Mutation rewiring degron network	0.1389
p.A421V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	409:415	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TACC2

UniProt ID: O95359

Entrez ID: 10579

Protein name: Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TACC2 in