DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_APCC_DBOX_1

Location: 937:945

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7404

ASA_SCORE: 95.4111

COIL: 0.9037

CONS_SCORE: 0.4204

DSS_SCORE: 0.6643

HELIX: 0.0461

FCONS_SCORE: 1.1001

RIG_SCORE: 0.6867

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A943V	TCGA-2A-A8W3	PRAD	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	0.5825
p.A943V	DO51309	PRAD	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.5825
p.E930Q	TCGA-A8-A09G	BRCA	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	0.1389
p.E930Q	DO1990	BRCA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.1389
p.K940T	TCGA-BR-4280	STAD	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	0.6195
p.K940T	DO38663	STAD	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.6195
p.E946K	TCGA-D3-A8GL	SKCM	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	0.3056
p.E946K	DO220868	MELA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.3056
p.E946K	DO50287	SKCM	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.3056
p.G954S	TCGA-F4-6570	COAD	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	0.0833
p.G954S	DO10443	COAD	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.0833
p.E950K	TCGA-G2-A2ES	BLCA	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	0.1944
p.E950K	DO785	BLCA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.1944
p.E929V	TCGA-XY-A8S2	TGCT	TCGA	TRQKLPALG	DEG_APCC_DBOX_1	0.1111
p.R948Q	DO233151	GACA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.25
p.K947R	DO233098	GACA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.2778
p.P942R	DO220871	MELA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.6401
p.G951E	DO219878	SKCA	ICGC	TRQKLPALG	DEG_APCC_DBOX_1	0.1667
p.S934A	SIDM00336	Melanoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	0.25
p.S934A	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	0.25
p.S934A	SIDM01766	Chondrosarcoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	0.25
p.K940R	SIDM01178	Other Solid Cancers	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	0.6126
p.K940R	SIDM01045	Endometrial Carcinoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	0.6126
p.R948W	SIDM00060	Ovarian Carcinoma	GDSC	TRQKLPALG	DEG_APCC_DBOX_1	0.25
p.K935E	ACH-000702	Lymphoma	CCLE	TRQKLPALG	DEG_APCC_DBOX_1	0.2778
p.K935E	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	0.2778
p.A938V	ACH-000994	Endometrial/Uterine Cancer	CCLE	TRQKLPALG	DEG_APCC_DBOX_1	0.6936
p.A940V	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	0.6936
p.K947E	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	0.2778
p.Q949R	MFE-319	endometrium	COSMIC	TRQKLPALG	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRQKLPALG

Degron related mutations and impact score

Drug responses associated with TACC2 mutations

All proteins holding degron of TRQKLPALG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_APCC_DBOX_1	937:945	TRQKLPALG	APC,CDC20,FZR1	0.7404	More...