DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_SCF_FBW7_2

Location: 409:415

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 103.2429

COIL: 0.9269

CONS_SCORE: 0.4009

DSS_SCORE: 0.6608

HELIX: 0.05

FCONS_SCORE: 1.0964

RIG_SCORE: 0.6651

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S408F	TCGA-13-0920	OV	TCGA	LLTPTEE	DEG_SCF_FBW7_2	0.3056
p.S408F	DO28099	OV	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.3056
p.A423T	TCGA-AX-A0J1	UCEC	TCGA	LLTPTEE	DEG_SCF_FBW7_2	0.1111
p.A423T	DO41199	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.1111
p.P402S	TCGA-BS-A0UF	UCEC	TCGA	LLTPTEE	DEG_SCF_FBW7_2	0.1389
p.P402S	DO41488	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.1389
p.A416T	TCGA-EA-A410	CESC	TCGA	LLTPTEE	DEG_SCF_FBW7_2	0.3056
p.A416T	DO49929	CESC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.3056
p.G399R	DO229505	LAML	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00216	Colorectal Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00064	Hepatocellular Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00411	Pancreatic Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00535	Chondrosarcoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00370	T-Lymphoblastic Leukemia	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00590	Oral Cavity Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00568	Gastric Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00817	Kidney Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00580	Acute Myeloid Leukemia	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM01257	Hepatocellular Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM01033	Bladder Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00531	Pancreatic Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM01770	Gastric Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM01320	Pancreatic Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM00062	Hepatocellular Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.G399R	SIDM01442	Glioma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.L401F	DO229009	LICA	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.1111
p.S424L	DO222402	MELA	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.0833
p.D421N	DO222714	MELA	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.1667
p.S399F	DO37819	SKCM	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.0556
p.P403L	DO48665	SKCM	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.1667
p.P403H	DO219787	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.1667
p.A409V	DO42105	UCEC	ICGC	LLTPTEE	DEG_SCF_FBW7_2	0.6936
p.E414K	SIDM00589	Oral Cavity Carcinoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.591
p.E414K	ACH-000778	Head and Neck Cancer	CCLE	LLTPTEE	DEG_SCF_FBW7_2	0.591
p.E414K	HSC-3	upper_aerodigestive_tract	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.591
p.E414D	SIDM01316	Ewing's Sarcoma	GDSC	LLTPTEE	DEG_SCF_FBW7_2	0.5647
p.P412L	ACH-000593	Bladder Cancer	CCLE	LLTPTEE	DEG_SCF_FBW7_2	0.7582
p.L407P	OE21	oesophagus	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.2778
p.L407P	VMRC-RCW	kidney	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.2778
p.L407P	Saos-2	bone	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.2778
p.L407P	MCF7	breast	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.2778
p.V409I	KYSE-50	oesophagus	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.7076
p.A417V	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.2778
p.A421V	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPTEE	DEG_SCF_FBW7_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLTPTEE

Degron related mutations and impact score

Drug responses associated with TACC2 mutations

All proteins holding degron of LLTPTEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SCF_FBW7_2	409:415	LLTPTEE	FBXW7	0.9948	More...