DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_SIAH_1

Location: 726:734

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8759

ASA_SCORE: 91.6667

COIL: 0.9212

CONS_SCORE: 0.3865

DSS_SCORE: 0.6737

HELIX: 0.0334

FCONS_SCORE: 0.9015

RIG_SCORE: 0.7229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P727H	TCGA-AA-3977	COAD	TCGA	TPVAEVAPK	DEG_SIAH_1	0.7694
p.P727H	DO8730	COAD	ICGC	TPVAEVAPK	DEG_SIAH_1	0.7694
p.H741Y	DO1954	BRCA	ICGC	TPVAEVAPK	DEG_SIAH_1	0.1389
p.A719V	DO28119	OV	ICGC	TPVAEVAPK	DEG_SIAH_1	0.1389
p.A719V	DO41235	UCEC	ICGC	TPVAEVAPK	DEG_SIAH_1	0.1389
p.S737G	DO51776	STAD	ICGC	TPVAEVAPK	DEG_SIAH_1	0.25
p.K734N	SIDM00373	Endometrial Carcinoma	GDSC	TPVAEVAPK	DEG_SIAH_1	0.5806
p.K734N	ACH-000974	Endometrial/Uterine Cancer	CCLE	TPVAEVAPK	DEG_SIAH_1	0.5806
p.V731I	ACH-000372	Leukemia	CCLE	TPVAEVAPK	DEG_SIAH_1	0.7076
p.V731I	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.7076
p.G727D	TASK1	bone	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.7198
p.G727D	EBC-1	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.7198
p.H729P	NCI-H2170	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.7694
p.H729P	NCI-H520	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.7694
p.H741P	NCI-H2170	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.1389
p.H741P	NCI-H520	lung	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.1389
p.P716L	KYSE-450	oesophagus	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.0556
p.V743I	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	TPVAEVAPK	DEG_SIAH_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SIAH_1	726:734	TPVAEVAPK	SIAH1,SIAH2,SIAH3	0.8759	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons