DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_SCF_FBW7_1

Location: 910:917

E3 ligase: FBXW7

DEGRON score: 0.949

ASA_SCORE: 89.85

COIL: 0.9511

CONS_SCORE: 0.4205

DSS_SCORE: 0.7052

HELIX: 0.0185

FCONS_SCORE: 1.1279

RIG_SCORE: 0.5985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W923C	TCGA-13-2061	OV	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	0.1667
p.W923C	DO27970	OV	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.1667
p.Q904E	TCGA-55-8204	LUAD	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	0.1667
p.Q904E	DO45322	LUAD	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.1667
p.S926Y	TCGA-B5-A11E	UCEC	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	0.0833
p.S926Y	DO41644	UCEC	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.0833
p.Q904H	TCGA-DD-A4NH	LIHC	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	0.1667
p.Q904H	DO44907	LIHC	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.1667
p.P918T	TCGA-EE-A2MG	SKCM	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	0.3056
p.P918T	DO37421	SKCM	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.3056
p.G908S	TCGA-FS-A1ZZ	SKCM	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	0.2778
p.G908S	DO37412	SKCM	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.2778
p.S925I	TCGA-KK-A8IG	PRAD	TCGA	LSDTPTSS	DEG_SCF_FBW7_1	0.1111
p.S925I	DO219331	PRAD	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.1111
p.L910M	DO229389	BTCA	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.5999
p.D914N	DO220862	MELA	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.6932
p.D914N	DO37839	SKCM	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.6932
p.G908C	DO232352	PBCA	ICGC	LSDTPTSS	DEG_SCF_FBW7_1	0.2778
p.T906A	SNU-1040	large_intestine	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	0.2222
p.K917R	MEL-HO	skin	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	0.7237
p.K905E	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	0.1944
p.K917E	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	0.7022
p.E909Q	NTERA-2_cl_D1	testis	COSMIC	LSDTPTSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SCF_FBW7_1	910:917	LSDTPTSS	FBXW7	0.949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons