DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_SPOP_SBC_1

Location: 2349:2353

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 69.72

COIL: 0.831

CONS_SCORE: 0.6818

DSS_SCORE: 0.6184

HELIX: 0.1132

FCONS_SCORE: 1.1128

RIG_SCORE: 0.6979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2351F	TCGA-BF-AAP7	SKCM	TCGA	PFSST	DEG_SPOP_SBC_1	0.7982
p.K2355I	TCGA-DU-6407	LGG	TCGA	PFSST	DEG_SPOP_SBC_1	0.2778
p.F2350V	TCGA-KK-A8I6	PRAD	TCGA	PFSST	DEG_SPOP_SBC_1	0.5957
p.A2359S	DO229028	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC	DEG_SPOP_SBC_1	81:85	PFSST	SPOP	0.9486	More...
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	2349:2353	PFSST	SPOP	0.9988	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1013:1017	PFSST	SPOP	0.9797	More...
Q9UNF0	Protein kinase C and casein kinase substrate in neurons protein 2	DEG_SPOP_SBC_1	406:410	PFSST	SPOP	0.9979	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	234:238	PFSST	SPOP	0.9598	More...
Q53SZ7	Proline-rich protein 30	DEG_SPOP_SBC_1	50:54	PFSST	SPOP	0.8135	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons