DegronMD - O75808(CAPN15)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G313S	TCGA-22-1012	LUSC	TCGA	AGSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.5882
p.G313S	DO27302	LUSC	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.5882
p.T307S	TCGA-EB-A5UL	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1944
p.T307S	DO47601	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1944
p.R309S	TCGA-EI-6507	READ	TCGA	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.25
p.R309S	DO36675	READ	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.25
p.P230Q	TCGA-EM-A22L	THCA	TCGA	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222
p.P230Q	DO38923	THCA	ICGC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222
p.V310I	TCGA-UY-A78K	BLCA	TCGA	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.V310I	DO219031	BLCA	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.V310I	ACH-000999	Colon/Colorectal Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.E304D	DO225132	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1111
p.E304D	ACH-001796	Liposarcoma	CCLE	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1111
p.S319G	DO222919	BTCA	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.25
p.R309H	DO229005	COCA	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.25
p.S319I	DO229008	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.25
p.S314R	DO50938	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7427
p.N241S	SIDM00227	Neuroblastoma	GDSC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.N241S	ACH-001344	Neuroblastoma	CCLE	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.N241S	GI-ME-N	autonomic ganglia	COSMIC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.V244M	SIDM01039	Other Solid Cancers	GDSC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667
p.V244M	ACH-001529	Endometrial/Uterine Cancer	CCLE	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667
p.V244M	JAR	placenta	COSMIC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667
p.T303M	SIDM01051	Ovarian Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.T303M	ACH-000936	Ovarian Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.T303M	EFO-27	ovary	COSMIC	AGSST	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.P226S	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.P226S	ACH-000873	Esophageal Cancer	CCLE	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.F232I	SIDM00056	Thyroid Gland Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.F232I	ACH-002148	Thyroid Cancer	CCLE	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.F232I	K5	thyroid	COSMIC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.P243L	SIDM01574	Plasma Cell Myeloma	GDSC	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1944
p.P243L	ACH-000588	Myeloma	CCLE	PFSST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAPN15

UniProt ID: O75808

Entrez ID: 6650

Protein name: Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CAPN15 in