DegronMD

Uniprot ID: O75808

Source protein: Calpain-15

Source gene: CAPN15

Class: DEG_SPOP_SBC_1

Location: 312:316

E3 ligase: SPOP

DEGRON score: 0.9799

ASA_SCORE: 65.78

COIL: 0.8242

CONS_SCORE: 0.3105

DSS_SCORE: 0.5671

HELIX: 0.0954

FCONS_SCORE: 1.0412

RIG_SCORE: 0.6139

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G313S	TCGA-22-1012	LUSC	TCGA	AGSST	DEG_SPOP_SBC_1	0.5882
p.G313S	DO27302	LUSC	ICGC	AGSST	DEG_SPOP_SBC_1	0.5882
p.T307S	TCGA-EB-A5UL	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	0.1944
p.T307S	DO47601	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	0.1944
p.R309S	TCGA-EI-6507	READ	TCGA	AGSST	DEG_SPOP_SBC_1	0.25
p.R309S	DO36675	READ	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.V310I	TCGA-UY-A78K	BLCA	TCGA	AGSST	DEG_SPOP_SBC_1	0.2778
p.V310I	DO219031	BLCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.2778
p.V310I	ACH-000999	Colon/Colorectal Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.2778
p.E304D	DO225132	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.1111
p.E304D	ACH-001796	Liposarcoma	CCLE	AGSST	DEG_SPOP_SBC_1	0.1111
p.S319G	DO222919	BTCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.R309H	DO229005	COCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.S319I	DO229008	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.S314R	DO50938	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	0.7427
p.T303M	SIDM01051	Ovarian Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.0833
p.T303M	ACH-000936	Ovarian Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.0833
p.T303M	EFO-27	ovary	COSMIC	AGSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons