DegronMD - P55198(MLLT6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S277L	TCGA-A5-A0G2	UCEC	TCGA	SILTPPVVPTA	DEG_COP1_1	261:271	Mutation rewiring degron network	0.1667
p.S277L	TCGA-A5-A0G2	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.S277L	DO41235	UCEC	ICGC	SILTPPVVPTA	DEG_COP1_1	261:271	Mutation rewiring degron network	0.1667
p.S277L	DO41235	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.S592N	TCGA-A5-A0G2	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.25
p.S592N	DO41235	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.25
p.S323N	TCGA-A6-5665	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.S323N	DO9756	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.R568Q	TCGA-AP-A0LM	UCEC	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.2778
p.R568Q	TCGA-AP-A0LM	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.R568Q	DO43306	UCEC	ICGC	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.2778
p.R568Q	DO43306	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.R568Q	ACH-000961	Endometrial/Uterine Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.2778
p.R568Q	ACH-000961	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.S258L	TCGA-AP-A1DK	UCEC	TCGA	SILTPPVVPTA	DEG_COP1_1	261:271	Mutation blocking phosphorylation signal	0.6944
p.S258L	DO42033	UCEC	ICGC	SILTPPVVPTA	DEG_COP1_1	261:271	Mutation blocking phosphorylation signal	0.6944
p.G999V	TCGA-AP-A1DK	UCEC	TCGA	AGSST	DEG_SPOP_SBC_1	998:1002	Mutation altering degron motif	0.6421
p.G999V	DO234307	ESAD	ICGC	AGSST	DEG_SPOP_SBC_1	998:1002	Mutation altering degron motif	0.6421
p.G999V	DO42033	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	998:1002	Mutation altering degron motif	0.6421
p.S606Y	TCGA-AX-A2HC	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S606Y	DO41572	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1389
p.S281F	TCGA-D3-A8GK	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7982
p.S281F	DO50286	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7982
p.S281F	ACH-000806	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7982
p.P601S	TCGA-EE-A29L	SKCM	TCGA	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.2778
p.P601S	DO37835	SKCM	ICGC	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.2778
p.S561F	TCGA-FS-A1ZZ	SKCM	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.0833
p.S561F	DO37412	SKCM	ICGC	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.0833
p.S594C	TCGA-FW-A3TU	SKCM	TCGA	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.3056
p.S594C	DO37441	SKCM	ICGC	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.3056
p.G565R	TCGA-HU-A4H8	STAD	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1944
p.G565R	TCGA-HU-A4H8	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.G565R	DO47869	STAD	ICGC	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1944
p.G565R	DO47869	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.L575F	TCGA-QR-A70H	PCPG	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.587
p.L575F	TCGA-QR-A70H	PCPG	TCGA	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.587
p.T291S	TCGA-W2-A7H7	PCPG	TCGA	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0833
p.G290E	DO532	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1111
p.R317W	DO5521	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.Q279K	DO227745	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.6944
p.I286T	DO11531	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.S336F	DO49537	LAML	ICGC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.S336F	DO231268	LAML	ICGC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.S335F	DO222542	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.R593L	DO231530	NBL	ICGC	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.2778
p.S261N	DO232224	PBCA	ICGC	SILTPPVVPTA	DEG_COP1_1	261:271	Mutation altering degron motif	0.818
p.S331F	DO229459	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.9093
p.S335P	DO229272	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.A1007V	SIDM01015	Chronic Myelogenous Leukemia	GDSC	AGSST	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1944
p.A1007V	SIDM00948	Burkitt's Lymphoma	GDSC	AGSST	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1944
p.A327T	SIDM00128	Head and Neck Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.A327T	SIDM00190	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.A327T	SIDM01162	Kidney Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.A327T	SIDM00156	Neuroblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.A327T	SIDM01097	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.A327T	SIDM00767	Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.A327T	SIDM00819	Kidney Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.A327T	SIDM01715	Non-Cancerous	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7139
p.P574T	SIDM00660	Colorectal Carcinoma	GDSC	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.7031
p.P574T	SIDM00660	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.7031
p.P574T	ACH-000985	Colon/Colorectal Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation altering degron motif	0.7031
p.P574T	ACH-000985	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.7031
p.R590H	SIDM00217	Colorectal Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1944
p.R590H	ACH-000999	Colon/Colorectal Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.1944
p.R568W	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.2778
p.R568W	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.G320D	SIDM01612	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.G320D	ACH-000946	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.T585P	ACH-000348	Skin Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1111
p.T585P	ACH-000348	Skin Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.T585P	ACH-000348	Skin Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.0556
p.T585P	ACH-000714	Myeloma	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1111
p.T585P	ACH-000714	Myeloma	CCLE	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.T585P	ACH-000714	Myeloma	CCLE	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.0556
p.T585P	ACH-000918	Leukemia	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1111
p.T585P	ACH-000918	Leukemia	CCLE	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.T585P	ACH-000918	Leukemia	CCLE	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.0556
p.T585P	ACH-002187	Kidney Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	570:577	Mutation rewiring degron network	0.1111
p.T585P	ACH-002187	Kidney Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.T585P	ACH-002187	Kidney Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	595:599	Mutation rewiring degron network	0.0556
p.F324C	ACH-001409	Bladder Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLLT6

UniProt ID: P55198

Entrez ID: 4302

Protein name: Protein AF-17 (ALL1-fused gene from chromosome 17 protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MLLT6 in