DegronMD

Uniprot ID: P55198

Source protein: Protein AF-17

Source gene: MLLT6

Class: DEG_SPOP_SBC_1

Location: 595:599

E3 ligase: SPOP

DEGRON score: 0.9496

ASA_SCORE: 96.94

COIL: 0.949

CONS_SCORE: 0.4503

DSS_SCORE: 0.4175

HELIX: 0.0256

FCONS_SCORE: 0.9612

RIG_SCORE: 0.6729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S592N	TCGA-A5-A0G2	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	0.25
p.S592N	DO41235	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	0.25
p.S606Y	TCGA-AX-A2HC	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	0.1389
p.S606Y	DO41572	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	0.1389
p.P601S	TCGA-EE-A29L	SKCM	TCGA	PFTST	DEG_SPOP_SBC_1	0.2778
p.P601S	DO37835	SKCM	ICGC	PFTST	DEG_SPOP_SBC_1	0.2778
p.S594C	TCGA-FW-A3TU	SKCM	TCGA	PFTST	DEG_SPOP_SBC_1	0.3056
p.S594C	DO37441	SKCM	ICGC	PFTST	DEG_SPOP_SBC_1	0.3056
p.R593L	DO231530	NBL	ICGC	PFTST	DEG_SPOP_SBC_1	0.2778
p.R590H	SIDM00217	Colorectal Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	0.1944
p.R590H	ACH-000999	Colon/Colorectal Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	0.1944
p.T585P	ACH-000348	Skin Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	0.0556
p.T585P	ACH-000714	Myeloma	CCLE	PFTST	DEG_SPOP_SBC_1	0.0556
p.T585P	ACH-000918	Leukemia	CCLE	PFTST	DEG_SPOP_SBC_1	0.0556
p.T585P	ACH-002187	Kidney Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons