DegronMD

Uniprot ID: Q8TDD2

Source protein: Transcription factor Sp7

Source gene: SP7

Class: DEG_SPOP_SBC_1

Location: 67:71

E3 ligase: SPOP

DEGRON score: 0.9975

ASA_SCORE: 56.74

COIL: 0.8304

CONS_SCORE: 0.5588

DSS_SCORE: 0.463

HELIX: 0.0618

FCONS_SCORE: 0.9476

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D62N	TCGA-FW-A3R5	SKCM	TCGA	PFTST	DEG_SPOP_SBC_1	0.1944
p.D62N	DO37406	SKCM	ICGC	PFTST	DEG_SPOP_SBC_1	0.1944
p.F68L	TCGA-G2-A3VY	BLCA	TCGA	PFTST	DEG_SPOP_SBC_1	0.587
p.F68L	DO590	BLCA	ICGC	PFTST	DEG_SPOP_SBC_1	0.587
p.F68L	SIDM00821	Kidney Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	0.587
p.F68L	RCC-AB	kidney	COSMIC	PFTST	DEG_SPOP_SBC_1	0.587
p.Y64N	DO228202	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	0.25
p.A63D	DO229027	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	0.2222
p.A78T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PFTST	DEG_SPOP_SBC_1	0.1389
p.A78T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PFTST	DEG_SPOP_SBC_1	0.1389
p.S68L	ACH-000771	Head and Neck Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	0.7667
p.Y70C	ACH-000979	Prostate Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	0.7087
p.Y70C	DU-145	prostate	COSMIC	PFTST	DEG_SPOP_SBC_1	0.7087
p.A60T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PFTST	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons