DegronMD - Q13796(SHROOM2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1365M	TCGA-06-5416	GBM	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.8632
p.R1365M	DO10880	GBM	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.8632
p.G1135E	TCGA-28-1760	GBM	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.1944
p.G1135E	DO13725	GBM	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.1944
p.H154N	TCGA-28-5211	GBM	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.H154N	DO11016	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.R1017L	TCGA-43-A474	LUSC	TCGA	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.3056
p.R1017L	DO45490	LUSC	ICGC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.3056
p.P1016L	TCGA-44-A47A	LUAD	TCGA	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.2778
p.P1016L	DO23976	LUAD	ICGC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.2778
p.P1016L	SIDM00853	Other Sarcomas	GDSC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.2778
p.P1016L	ACH-000835	Sarcoma	CCLE	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.2778
p.P1016L	GCT	soft tissue	COSMIC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.2778
p.R1009L	TCGA-50-5930	LUAD	TCGA	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.0833
p.R1009L	DO25189	LUAD	ICGC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.0833
p.G742W	TCGA-53-7624	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.G742W	DO25058	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.P1027T	TCGA-55-A491	LUAD	TCGA	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.1389
p.P1027T	DO25787	LUAD	ICGC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.1389
p.D1354E	TCGA-77-7142	LUSC	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0556
p.D1354E	DO26462	LUSC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0556
p.S433N	TCGA-86-6851	LUAD	TCGA	PPLY	ITCH	429:432	Mutation rewiring degron network	0.3056
p.S433N	DO23798	LUAD	ICGC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.3056
p.K226N	TCGA-94-A4VJ	LUSC	TCGA	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.3056
p.K226N	DO50104	LUSC	ICGC	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.3056
p.R1555C	TCGA-A3-3383	KIRC	TCGA	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.25
p.R1555C	TCGA-D1-A174	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.25
p.R1555C	DO231251	PACA	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.25
p.R1555C	DO40900	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.25
p.S1120I	TCGA-A5-A0G1	UCEC	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.25
p.S1120I	DO42472	UCEC	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.25
p.E1133Q	TCGA-AC-A23H	BRCA	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.25
p.E1133Q	DO2401	BRCA	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.25
p.D1553N	TCGA-AC-A23H	BRCA	TCGA	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.3056
p.D1553N	DO2401	BRCA	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.3056
p.T229M	TCGA-AJ-A2QO	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7423
p.T229M	DO42177	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7423
p.A1545T	TCGA-AX-A1CE	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.25
p.A1545T	DO42280	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.25
p.E1556K	TCGA-AX-A2HC	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.2222
p.E1556K	DO41572	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.2222
p.R1020K	TCGA-B5-A11E	UCEC	TCGA	DYR	CBL_MET	1018:1020	Mutation altering degron motif	0.7237
p.R1020K	DO41644	UCEC	ICGC	DYR	CBL_MET	1018:1020	Mutation altering degron motif	0.7237
p.D1354N	TCGA-B5-A11E	UCEC	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0556
p.D1354N	DO41644	UCEC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0556
p.D155N	TCGA-B5-A1MR	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.D155N	DO41758	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.L431P	TCGA-B5-A3FC	UCEC	TCGA	PPLY	ITCH	429:432	Mutation altering degron motif	0.6471
p.L431P	DO41871	UCEC	ICGC	PPLY	ITCH	429:432	Mutation altering degron motif	0.6471
p.S425N	TCGA-BS-A0U8	UCEC	TCGA	PPLY	ITCH	429:432	Mutation rewiring degron network	0.2222
p.S425N	DO41380	UCEC	ICGC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.2222
p.D441N	TCGA-CV-5970	HNSC	TCGA	PPLY	ITCH	429:432	Mutation rewiring degron network	0.0833
p.D441N	DO14280	HNSC	ICGC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.0833
p.S218N	TCGA-D1-A1NY	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0833
p.S218N	DO42512	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0833
p.G1135R	TCGA-D3-A3C7	SKCM	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.1944
p.G1135R	DO47569	SKCM	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.1944
p.R1134S	TCGA-DS-A0VN	CESC	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.2222
p.R1134S	DO6269	CESC	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation rewiring degron network	0.2222
p.S151Y	TCGA-E6-A1LX	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.712
p.S151Y	TCGA-EO-A22X	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.712
p.S151Y	DO41020	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.712
p.S151Y	DO43907	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.712
p.S737L	TCGA-EE-A3JA	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	735:739	Mutation altering degron motif	0.7667
p.S737L	DO47625	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation altering degron motif	0.7667
p.A130V	TCGA-EO-A22U	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25
p.A130V	DO43755	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25
p.D434N	TCGA-EO-A3AV	UCEC	TCGA	PPLY	ITCH	429:432	Mutation rewiring degron network	0.2778
p.D434N	DO52412	UCEC	ICGC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.2778
p.S125G	TCGA-EO-A3KX	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.5556
p.S125G	DO219774	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.5556
p.W160L	TCGA-ER-A19F	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.W160L	DO37679	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.H222N	TCGA-G7-6797	KIRP	TCGA	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.1944
p.H222N	DO20917	KIRP	ICGC	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.1944
p.G145S	TCGA-OL-A5DA	BRCA	TCGA	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.G145S	TCGA-OL-A5DA	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.G145S	DO44121	BRCA	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.G145S	DO44121	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.G145S	SIDM00489	Oral Cavity Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.G145S	SIDM00489	Oral Cavity Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.G145S	SIDM00792	Small Cell Lung Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.G145S	SIDM00792	Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.G145S	NCI-H1688	lung	COSMIC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.G145S	NCI-H1688	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.G145S	Ca9-22	upper aerodigestive tract	COSMIC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.G145S	Ca9-22	upper aerodigestive tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.S442R	TCGA-S9-A6TZ	LGG	TCGA	PPLY	ITCH	429:432	Mutation rewiring degron network	0.0556
p.S442R	DO48588	LGG	ICGC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.0556
p.A149T	TCGA-SW-A7EA	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7139
p.A149T	DO50685	ORCA	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7139
p.A149T	DO51749	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7139
p.L1367V	TCGA-X6-A8C4	SARC	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.5654
p.L1367V	DO220321	SARC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.5654
p.S142F	DO222364	BTCA	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.S142F	DO222364	BTCA	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.S1022L	DO222486	BTCA	ICGC	DYR	CBL_MET	1018:1020	Mutation blocking phosphorylation signal	0.7222
p.S1022L	DO50325	ESAD	ICGC	DYR	CBL_MET	1018:1020	Mutation blocking phosphorylation signal	0.7222
p.S1022L	SIDM00561	Other Blood Cancers	GDSC	DYR	CBL_MET	1018:1020	Mutation blocking phosphorylation signal	0.7222
p.S1022L	ACH-002274	Leukemia	CCLE	DYR	CBL_MET	1018:1020	Mutation blocking phosphorylation signal	0.7222
p.S1022L	MLMA	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1018:1020	Mutation blocking phosphorylation signal	0.7222
p.R1009W	DO222421	BTCA	ICGC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.0833
p.R1017Q	DO222884	COCA	ICGC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.3056
p.R1557H	DO233119	GACA	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.1944
p.R1557H	DO52365	LUSC	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.1944
p.R1557H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.1944
p.R1557H	SIDM00489	Oral Cavity Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.1944
p.R1557H	SIDM00241	Breast Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.1944
p.E1355K	DO233076	GACA	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0833
p.E1355K	SIDM01951	Colorectal Carcinoma	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0833
p.R1364W	DO233620	GACA	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.7523
p.L156R	DO233946	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.S218C	DO228926	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0833
p.A131S	DO229019	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2778
p.C140F	DO229041	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25
p.C140F	DO229041	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0833
p.P127L	DO229054	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.R747L	DO229006	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1111
p.R1375I	DO45037	LINC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.25
p.G742E	DO220909	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.P1127R	DO222595	MELA	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation altering degron motif	0.7512
p.H126Q	DO232826	NACA	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1389
p.Q734K	DO46384	OV	ICGC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.3056
p.A1545V	DO37409	SKCM	ICGC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.25
p.P133T	DO229253	THCA	ICGC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7031
p.S436I	DO42673	UCEC	ICGC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.2222
p.P437S	SIDM00458	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.1944
p.P437S	SIDM00087	Plasma Cell Myeloma	GDSC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.1944
p.P437S	SIDM00694	Other Solid Cancers	GDSC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.1944
p.P437S	SIDM00539	Esophageal Carcinoma	GDSC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.1944
p.L732Q	SIDM01265	Plasma Cell Myeloma	GDSC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.L732Q	SIDM00720	Mesothelioma	GDSC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.L732Q	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.H744Q	SIDM00789	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1944
p.H744Q	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1944
p.H744Q	ACH-001061	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1944
p.E1355D	SIDM00789	Colorectal Carcinoma	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0833
p.E1355D	ACH-000997	Colon/Colorectal Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0833
p.E1355D	ACH-001061	Colon/Colorectal Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0833
p.E1355D	HCT-15	large intestine	COSMIC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.0833
p.T137A	SIDM00633	Breast Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7139
p.P1369S	SIDM00007	Other Solid Cancers	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.5641
p.P1369S	ACH-001550	Skin Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.5641
p.P1369S	MCC13	skin	COSMIC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation altering degron motif	0.5641
p.R146Q	SIDM00351	Oral Cavity Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.R146Q	SIDM00351	Oral Cavity Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.R146Q	SIDM01776	Plasma Cell Myeloma	GDSC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.R146Q	SIDM01776	Plasma Cell Myeloma	GDSC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.R146Q	SAS	upper aerodigestive tract	COSMIC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.R146Q	SAS	upper aerodigestive tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.25
p.G1010S	SIDM00854	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.1111
p.G1010S	GA-10	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1018:1020	Mutation rewiring degron network	0.1111
p.E1547D	SIDM00346	Chronic Myelogenous Leukemia	GDSC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.3056
p.E1547D	ACH-000301	Leukemia	CCLE	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.3056
p.E1547D	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.3056
p.P1127L	SIDM00003	Melanoma	GDSC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation altering degron motif	0.7582
p.P1127L	ACH-000884	Skin Cancer	CCLE	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation altering degron motif	0.7582
p.P1127L	ACH-002159	Skin Cancer	CCLE	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation altering degron motif	0.7582
p.P1127L	M14	skin	COSMIC	PQDTPKAT	DEG_SCF_FBW7_1	1123:1130	Mutation altering degron motif	0.7582
p.P745L	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1667
p.P745L	ACH-000353	Esophageal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1667
p.P745L	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1667
p.P745L	TE-15	oesophagus	COSMIC	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1667
p.S1376I	SIDM00118	Colorectal Carcinoma	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.2222
p.S1376I	ACH-001081	Colon/Colorectal Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.2222
p.S1376I	HCC2998	large intestine	COSMIC	RRKLLPKIP	DEG_APCC_DBOX_1	1364:1372	Mutation rewiring degron network	0.2222
p.E1550G	SIDM01617	Endometrial Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation altering degron motif	0.7199
p.E1550G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation altering degron motif	0.7199
p.E128K	SIDM01588	Endometrial Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.E128K	ACH-000993	Endometrial/Uterine Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.I748T	ACH-000520	Ovarian Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.0833
p.A232T	ACH-001063	Ovarian Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.3056
p.I1539T	ACH-001065	Breast Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.0833
p.I1539T	EVSA-T	breast	COSMIC	LKENL	DEG_APCC_KENBOX_2	1548:1552	Mutation rewiring degron network	0.0833
p.I420T	LS-180	large intestine	COSMIC	PPLY	ITCH	429:432	Mutation rewiring degron network	0.0833
p.D148H	ZR-75-30	breast	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.E143K	Sarc9371	bone	COSMIC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.E143K	Sarc9371	bone	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1667
p.V221M	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.1667
p.L149P	MFE-319	endometrium	COSMIC	ASSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7582
p.P124S	OVISE	ovary	COSMIC	PFTST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHROOM2

UniProt ID: Q13796

Entrez ID: 357

Protein name: Protein Shroom2 (Apical-like protein) (Protein APXL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHROOM2 in