DegronMD

Uniprot ID: Q13796

Source protein: Protein Shroom2

Source gene: SHROOM2

Class: DEG_SCF_FBW7_1

Location: 1123:1130

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 93.1375

COIL: 0.9274

CONS_SCORE: 0.172

DSS_SCORE: 0.5965

HELIX: 0.0435

FCONS_SCORE: 0.6764

RIG_SCORE: 0.6556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1135E	TCGA-28-1760	GBM	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	0.1944
p.G1135E	DO13725	GBM	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	0.1944
p.S1120I	TCGA-A5-A0G1	UCEC	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	0.25
p.S1120I	DO42472	UCEC	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	0.25
p.E1133Q	TCGA-AC-A23H	BRCA	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	0.25
p.E1133Q	DO2401	BRCA	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	0.25
p.G1135R	TCGA-D3-A3C7	SKCM	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	0.1944
p.G1135R	DO47569	SKCM	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	0.1944
p.R1134S	TCGA-DS-A0VN	CESC	TCGA	PQDTPKAT	DEG_SCF_FBW7_1	0.2222
p.R1134S	DO6269	CESC	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	0.2222
p.P1127R	DO222595	MELA	ICGC	PQDTPKAT	DEG_SCF_FBW7_1	0.7512
p.P1127L	SIDM00003	Melanoma	GDSC	PQDTPKAT	DEG_SCF_FBW7_1	0.7582
p.P1127L	ACH-000884	Skin Cancer	CCLE	PQDTPKAT	DEG_SCF_FBW7_1	0.7582
p.P1127L	ACH-002159	Skin Cancer	CCLE	PQDTPKAT	DEG_SCF_FBW7_1	0.7582
p.P1127L	M14	skin	COSMIC	PQDTPKAT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13796	Protein Shroom2	DEG_SCF_FBW7_1	1123:1130	PQDTPKAT	FBXW7	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons