DegronMD

Uniprot ID: Q13796

Source protein: Protein Shroom2

Source gene: SHROOM2

Class: DEG_APCC_DBOX_1

Location: 1364:1372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9953

ASA_SCORE: 123.3

COIL: 0.6768

CONS_SCORE: 0.3732

DSS_SCORE: 0.6025

HELIX: 0.3153

FCONS_SCORE: 1.006

RIG_SCORE: 0.6967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1365M	TCGA-06-5416	GBM	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	0.8632
p.R1365M	DO10880	GBM	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	0.8632
p.D1354E	TCGA-77-7142	LUSC	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	0.0556
p.D1354E	DO26462	LUSC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	0.0556
p.D1354N	TCGA-B5-A11E	UCEC	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	0.0556
p.D1354N	DO41644	UCEC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	0.0556
p.L1367V	TCGA-X6-A8C4	SARC	TCGA	RRKLLPKIP	DEG_APCC_DBOX_1	0.5654
p.L1367V	DO220321	SARC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	0.5654
p.E1355K	DO233076	GACA	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	0.0833
p.E1355K	SIDM01951	Colorectal Carcinoma	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	0.0833
p.R1364W	DO233620	GACA	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	0.7523
p.R1375I	DO45037	LINC	ICGC	RRKLLPKIP	DEG_APCC_DBOX_1	0.25
p.E1355D	SIDM00789	Colorectal Carcinoma	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	0.0833
p.E1355D	ACH-000997	Colon/Colorectal Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	0.0833
p.E1355D	ACH-001061	Colon/Colorectal Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	0.0833
p.E1355D	HCT-15	large_intestine	COSMIC	RRKLLPKIP	DEG_APCC_DBOX_1	0.0833
p.P1369S	SIDM00007	Other Solid Cancers	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	0.5641
p.P1369S	ACH-001550	Skin Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	0.5641
p.P1369S	MCC13	skin	COSMIC	RRKLLPKIP	DEG_APCC_DBOX_1	0.5641
p.S1376I	SIDM00118	Colorectal Carcinoma	GDSC	RRKLLPKIP	DEG_APCC_DBOX_1	0.2222
p.S1376I	ACH-001081	Colon/Colorectal Cancer	CCLE	RRKLLPKIP	DEG_APCC_DBOX_1	0.2222
p.S1376I	HCC2998	large_intestine	COSMIC	RRKLLPKIP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13796	Protein Shroom2	DEG_APCC_DBOX_1	1364:1372	RRKLLPKIP	APC,CDC20,FZR1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons