DegronMD

Uniprot ID: Q13796

Source protein: Protein Shroom2

Source gene: SHROOM2

Class: DEG_APCC_KENBOX_2

Location: 1548:1552

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8846

ASA_SCORE: 80.78

COIL: 0.053

CONS_SCORE: 0.5746

DSS_SCORE: 0.3077

HELIX: 0.9504

FCONS_SCORE: 1.3739

RIG_SCORE: 0.7844

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1550G	SIDM01617	Endometrial Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.7199
p.E1550G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	0.7199
p.D1553N	TCGA-AC-A23H	BRCA	TCGA	LKENL	DEG_APCC_KENBOX_2	0.3056
p.D1553N	DO2401	BRCA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.3056
p.E1547D	SIDM00346	Chronic Myelogenous Leukemia	GDSC	LKENL	DEG_APCC_KENBOX_2	0.3056
p.E1547D	ACH-000301	Leukemia	CCLE	LKENL	DEG_APCC_KENBOX_2	0.3056
p.E1547D	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.3056
p.R1555C	TCGA-A3-3383	KIRC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.25
p.R1555C	TCGA-D1-A174	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.25
p.R1555C	DO231251	PACA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.25
p.R1555C	DO40900	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.25
p.A1545T	TCGA-AX-A1CE	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.25
p.A1545T	DO42280	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.25
p.A1545V	DO37409	SKCM	ICGC	LKENL	DEG_APCC_KENBOX_2	0.25
p.E1556K	TCGA-AX-A2HC	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2222
p.E1556K	DO41572	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.R1557H	DO233119	GACA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.R1557H	DO52365	LUSC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.R1557H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.R1557H	SIDM00489	Oral Cavity Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.R1557H	SIDM00241	Breast Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.I1539T	ACH-001065	Breast Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	0.0833
p.I1539T	EVSA-T	breast	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.0833

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1N0	C-type lectin domain family 4 member F	DEG_APCC_KENBOX_2	288:292	LKENL	APC,CDC20,FZR1	0.6441	More...
Q7Z7A1	Centriolin	DEG_APCC_KENBOX_2	2203:2207	LKENL	APC,CDC20,FZR1	0.7087	More...
Q13796	Protein Shroom2	DEG_APCC_KENBOX_2	1548:1552	LKENL	APC,CDC20,FZR1	0.8846	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1894:1898	LKENL	APC,CDC20,FZR1	0.8715	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_APCC_KENBOX_2	155:159	LKENL	APC,CDC20,FZR1	0.6187	More...
Q16587	Zinc finger protein 74	DEG_APCC_KENBOX_2	22:26	LKENL	APC,CDC20,FZR1	0.6629	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons