DegronMD

Uniprot ID: Q8TF72

Source protein: Protein Shroom3

Source gene: SHROOM3

Class: DEG_APCC_KENBOX_2

Location: 1894:1898

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8715

ASA_SCORE: 83.1

COIL: 0.1098

CONS_SCORE: 0.6457

DSS_SCORE: 0.3596

HELIX: 0.8952

FCONS_SCORE: 1.4917

RIG_SCORE: 0.7695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1901W	TCGA-39-5034	LUSC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.25
p.R1901W	DO26854	LUSC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.25
p.Q1887H	TCGA-A5-A0G2	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.1389
p.Q1887H	DO41235	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1389
p.G1907D	TCGA-BR-8680	STAD	TCGA	LKENL	DEG_APCC_KENBOX_2	0.0833
p.G1907D	DO47769	STAD	ICGC	LKENL	DEG_APCC_KENBOX_2	0.0833
p.R1900C	TCGA-CA-6717	COAD	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2778
p.R1900C	DO8264	COAD	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2778
p.R1892W	TCGA-DC-5869	READ	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2778
p.R1892W	DO36584	READ	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2778
p.L1898M	TCGA-DX-AB2W	SARC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.5999
p.L1898M	DO220095	SARC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.5999
p.G1886V	TCGA-P6-A5OG	ACC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.1111
p.G1886V	DO228952	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.E1896Q	DO47156	RECA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.6744
p.R1900H	SIDM00216	Colorectal Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.2778
p.R1900H	ACH-000989	Colon/Colorectal Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	0.2778
p.R1900H	SNU-175	large_intestine	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13796	Protein Shroom2	DEG_APCC_KENBOX_2	1548:1552	LKENL	APC,CDC20,FZR1	0.8846	More...
Q16587	Zinc finger protein 74	DEG_APCC_KENBOX_2	22:26	LKENL	APC,CDC20,FZR1	0.6629	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_APCC_KENBOX_2	155:159	LKENL	APC,CDC20,FZR1	0.6187	More...
Q7Z7A1	Centriolin	DEG_APCC_KENBOX_2	2203:2207	LKENL	APC,CDC20,FZR1	0.7087	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1894:1898	LKENL	APC,CDC20,FZR1	0.8715	More...
Q8N1N0	C-type lectin domain family 4 member F	DEG_APCC_KENBOX_2	288:292	LKENL	APC,CDC20,FZR1	0.6441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons