DegronMD

Uniprot ID: Q7Z7A1

Source protein: Centriolin

Source gene: CNTRL

Class: DEG_APCC_KENBOX_2

Location: 2203:2207

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7087

ASA_SCORE: 114.2

COIL: 0.5414

CONS_SCORE: 0.5858

DSS_SCORE: 0.4587

HELIX: 0.4506

FCONS_SCORE: 0.9911

RIG_SCORE: 0.754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2194K	TCGA-BH-A203	BRCA	TCGA	LKENL	DEG_APCC_KENBOX_2	0.0833
p.E2194K	DO2156	BRCA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.0833
p.N2195H	SIDM00342	T-Lymphoblastic Leukemia	GDSC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.N2195H	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.P2215T	SIDM00279	Gastric Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13796	Protein Shroom2	DEG_APCC_KENBOX_2	1548:1552	LKENL	APC,CDC20,FZR1	0.8846	More...
Q16587	Zinc finger protein 74	DEG_APCC_KENBOX_2	22:26	LKENL	APC,CDC20,FZR1	0.6629	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_APCC_KENBOX_2	155:159	LKENL	APC,CDC20,FZR1	0.6187	More...
Q7Z7A1	Centriolin	DEG_APCC_KENBOX_2	2203:2207	LKENL	APC,CDC20,FZR1	0.7087	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1894:1898	LKENL	APC,CDC20,FZR1	0.8715	More...
Q8N1N0	C-type lectin domain family 4 member F	DEG_APCC_KENBOX_2	288:292	LKENL	APC,CDC20,FZR1	0.6441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons