DegronMD

Uniprot ID: Q16587

Source protein: Zinc finger protein 74

Source gene: ZNF74

Class: DEG_APCC_KENBOX_2

Location: 22:26

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6629

ASA_SCORE: 107.76

COIL: 0.6522

CONS_SCORE: 0.545

DSS_SCORE: 0.4852

HELIX: 0.3154

FCONS_SCORE: 0.9851

RIG_SCORE: 0.7403

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S30L	TCGA-AX-A0J1	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2222
p.S30L	TCGA-EE-A29S	SKCM	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2222
p.S30L	DO37936	SKCM	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.S30L	DO41199	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.E36K	TCGA-BT-A20O	BLCA	TCGA	LKENL	DEG_APCC_KENBOX_2	0.0556
p.E36K	DO460	BLCA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.0556
p.E36K	SIDM00568	Gastric Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.0556
p.E36K	SIDM00251	Gastric Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.0556
p.E36K	SIDM00381	Cervical Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.0556
p.S30W	TCGA-CC-A7II	LIHC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2222
p.S30W	DO52182	LIHC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.N25S	TCGA-LL-A6FQ	BRCA	TCGA	LKENL	DEG_APCC_KENBOX_2	0.7069
p.N25S	DO50054	BRCA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.7069
p.L33F	DO12712	GBM	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1389
p.S31P	DO49773	KIRP	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.H24Y	DO229052	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.7229
p.G14C	DO229009	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.T31A	DO231866	LINC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.V28M	DO229177	LMS	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2778
p.G36R	DO51761	STAD	ICGC	LKENL	DEG_APCC_KENBOX_2	0.0556
p.G14S	DO47785	STAD	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.G33C	DO229213	THCA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1389
p.P18H	DO229234	THCA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.W32L	SIDM00797	Melanoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.1667
p.W32L	ACH-000788	Skin Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	0.1667
p.W32L	A2058	skin	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.1667
p.P35A	SIDM00797	Melanoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.0833
p.P35A	ACH-000788	Skin Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	0.0833
p.P35A	A2058	skin	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.0833
p.P18S	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.P18S	ACH-000675	Lung Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	0.2222
p.P18S	NCI-H1734	lung	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.S23F	NCI-H1734	lung	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13796	Protein Shroom2	DEG_APCC_KENBOX_2	1548:1552	LKENL	APC,CDC20,FZR1	0.8846	More...
Q16587	Zinc finger protein 74	DEG_APCC_KENBOX_2	22:26	LKENL	APC,CDC20,FZR1	0.6629	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_APCC_KENBOX_2	155:159	LKENL	APC,CDC20,FZR1	0.6187	More...
Q7Z7A1	Centriolin	DEG_APCC_KENBOX_2	2203:2207	LKENL	APC,CDC20,FZR1	0.7087	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1894:1898	LKENL	APC,CDC20,FZR1	0.8715	More...
Q8N1N0	C-type lectin domain family 4 member F	DEG_APCC_KENBOX_2	288:292	LKENL	APC,CDC20,FZR1	0.6441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKENL

Degron related mutations and impact score

Drug responses associated with ZNF74 mutations

All proteins holding degron of LKENL