DegronMD - Q7Z7A1(CNTRL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1217N	TCGA-21-1079	LUSC	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.2222
p.D1217N	TCGA-21-1079	LUSC	TCGA	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.2778
p.D1217N	DO26846	LUSC	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.2222
p.D1217N	DO26846	LUSC	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.2778
p.P1204H	TCGA-37-3789	LUSC	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.3056
p.P1204H	DO26743	LUSC	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.3056
p.Y1244H	TCGA-41-2573	GBM	TCGA	PPGY	ITCH	1241:1244	Mutation altering degron motif	0.7229
p.Y1244H	DO12724	GBM	ICGC	PPGY	ITCH	1241:1244	Mutation altering degron motif	0.7229
p.D1219N	TCGA-A2-A0CR	BRCA	TCGA	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation altering degron motif	0.6932
p.D1219N	DO44163	BRCA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation altering degron motif	0.6932
p.D1217Y	TCGA-AP-A1DK	UCEC	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.2222
p.D1217Y	TCGA-AP-A1DK	UCEC	TCGA	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.2778
p.D1217Y	DO42033	UCEC	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.2222
p.D1217Y	DO42033	UCEC	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.2778
p.A667V	TCGA-B5-A3FC	UCEC	TCGA	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1667
p.A667V	DO41871	UCEC	ICGC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1667
p.E2194K	TCGA-BH-A203	BRCA	TCGA	LKENL	DEG_APCC_KENBOX_2	2203:2207	Mutation rewiring degron network	0.0833
p.E2194K	DO2156	BRCA	ICGC	LKENL	DEG_APCC_KENBOX_2	2203:2207	Mutation rewiring degron network	0.0833
p.M1245I	TCGA-BR-8680	STAD	TCGA	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.3056
p.M1245I	DO47769	STAD	ICGC	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.3056
p.A2296V	TCGA-D1-A103	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.2222
p.A2296V	DO42312	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.2222
p.S1207N	TCGA-EE-A182	SKCM	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.5958
p.S1207N	DO37814	SKCM	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.5958
p.S1207N	SIDM00318	Kidney Carcinoma	GDSC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.5958
p.S1207N	ACH-000484	Kidney Cancer	CCLE	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.5958
p.S1207N	VMRC-RCW	kidney	COSMIC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.5958
p.P1237S	TCGA-EE-A20C	SKCM	TCGA	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.2222
p.P1237S	DO220882	MELA	ICGC	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.2222
p.P1237S	DO222775	MELA	ICGC	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.2222
p.P1237S	DO47665	SKCM	ICGC	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.2222
p.S1220I	TCGA-EE-A2MG	SKCM	TCGA	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation altering degron motif	0.7341
p.S1220I	DO37421	SKCM	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation altering degron motif	0.7341
p.R1206M	TCGA-EE-A3AG	SKCM	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.8632
p.R1206M	DO37471	SKCM	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.8632
p.Q1233E	TCGA-F4-6703	COAD	TCGA	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.0833
p.Q1233E	TCGA-F4-6703	COAD	TCGA	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.1111
p.Q1233E	DO9908	COAD	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.0833
p.Q1233E	DO9908	COAD	ICGC	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.1111
p.A2293T	TCGA-G3-A5SL	LIHC	TCGA	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.3056
p.A2293T	DO44978	LIHC	ICGC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.3056
p.D2282N	TCGA-TN-A7HL	HNSC	TCGA	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1667
p.D2282N	DO219080	HNSC	ICGC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1667
p.Q1225E	DO228246	BRCA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.3056
p.L2287V	DO7042	CLLE	ICGC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.3056
p.E681K	DO50437	ESAD	ICGC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.591
p.G1221E	DO234437	ESAD	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation altering degron motif	0.7199
p.P1214A	DO223032	ESCA	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.3056
p.P1214A	DO223032	ESCA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation rewiring degron network	0.1944
p.S1224N	DO11854	GBM	ICGC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation altering degron motif	0.7069
p.V1249L	DO228976	LICA	ICGC	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.1944
p.S682I	DO229018	LICA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.3056
p.A683S	DO229026	LICA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2778
p.M668I	DO229041	LICA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1944
p.S1254F	DO229054	LICA	ICGC	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.0556
p.S2290R	DO46957	RECA	ICGC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation altering degron motif	0.8538
p.L684P	DO229272	THCA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.D2294Y	SIDM02059	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.2778
p.N672I	SIDM01175	Other Sarcomas	GDSC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.3056
p.N672I	ACH-002309	Sarcoma	CCLE	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.3056
p.N672I	SW684	soft tissue	COSMIC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.3056
p.R2278S	SIDM01178	Other Solid Cancers	GDSC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.0556
p.R2278S	ACH-002200	Skin Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.0556
p.R2278S	SW962	vulva	COSMIC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.0556
p.N2195H	SIDM00342	T-Lymphoblastic Leukemia	GDSC	LKENL	DEG_APCC_KENBOX_2	2203:2207	Mutation rewiring degron network	0.1111
p.N2195H	LOUCY	haematopoietic and lymphoid tissue	COSMIC	LKENL	DEG_APCC_KENBOX_2	2203:2207	Mutation rewiring degron network	0.1111
p.A2283V	SIDM00373	Endometrial Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1944
p.A2283V	ACH-000974	Endometrial/Uterine Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1944
p.A2283V	ACH-002026	Endometrial/Uterine Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1944
p.A2283V	SNG-M	endometrium	COSMIC	VTSTS	DEG_SPOP_SBC_1	2288:2292	Mutation rewiring degron network	0.1944
p.P2215T	SIDM00279	Gastric Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	2203:2207	Mutation rewiring degron network	0.1111
p.V666G	SIDM00164	Biliary Tract Carcinoma	GDSC	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1389
p.V666G	ACH-000209	Bile Duct Cancer	CCLE	MRKELAELE	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1389
p.M1246V	ACH-000300	Kidney Cancer	CCLE	PPGY	ITCH	1241:1244	Mutation rewiring degron network	0.2778
p.E1210K	MKN1	stomach	COSMIC	IRSGLHKLF	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.7022
p.K1243R	SW900	lung	COSMIC	PPGY	ITCH	1241:1244	Mutation altering degron motif	0.7237
p.R1224Q	HT-115	large intestine	COSMIC	DSGGDS	DEG_SCF_TRCP1_1	1219:1224	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNTRL

UniProt ID: Q7Z7A1

Entrez ID: 11064

Protein name: Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNTRL in