DegronMD

Uniprot ID: Q7Z7A1

Source protein: Centriolin

Source gene: CNTRL

Class: DEG_SCF_TRCP1_1

Location: 1219:1224

E3 ligase: BTRC

DEGRON score: 0.9523

ASA_SCORE: 86.3

COIL: 0.9495

CONS_SCORE: 0.5574

DSS_SCORE: 0.8163

HELIX: 0.0438

FCONS_SCORE: 1.0074

RIG_SCORE: 0.5288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1217N	TCGA-21-1079	LUSC	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.2778
p.D1217N	DO26846	LUSC	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.2778
p.D1219N	TCGA-A2-A0CR	BRCA	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.6932
p.D1219N	DO44163	BRCA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.6932
p.D1217Y	TCGA-AP-A1DK	UCEC	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.2778
p.D1217Y	DO42033	UCEC	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.2778
p.S1220I	TCGA-EE-A2MG	SKCM	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.7341
p.S1220I	DO37421	SKCM	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.7341
p.Q1233E	TCGA-F4-6703	COAD	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.0833
p.Q1233E	DO9908	COAD	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.0833
p.Q1225E	DO228246	BRCA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.3056
p.G1221E	DO234437	ESAD	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.7199
p.P1214A	DO223032	ESCA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.1944
p.S1224N	DO11854	GBM	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.7069
p.R1224Q	HT-115	large_intestine	COSMIC	DSGGDS	DEG_SCF_TRCP1_1	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons