DegronMD

Uniprot ID: P41227

Source protein: N-alpha-acetyltransferase 10

Source gene: NAA10

Class: DEG_SCF_TRCP1_1

Location: 204:209

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 66.8

COIL: 0.7875

CONS_SCORE: 0.3531

DSS_SCORE: 0.6908

HELIX: 0.1402

FCONS_SCORE: 1.2821

RIG_SCORE: 0.565

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D208H	DO26560	LUSC	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.6577
p.D208G	TCGA-HT-A616	LGG	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.6087
p.D208G	NCI-H2141	lung	COSMIC	DSGGDS	DEG_SCF_TRCP1_1	0.6087
p.D208E	TCGA-25-2404	OV	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.5647
p.T203I	DO42985	UCEC	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.3056
p.S212I	DO16023	HNSC	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.25
p.G199C	TCGA-D3-A1QA	SKCM	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.1944
p.E199K	DO222973	BTCA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.1944
p.E196K	TCGA-EY-A549	UCEC	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.1111
p.D217N	DO233855	GACA	ICGC	DSGGDS	DEG_SCF_TRCP1_1	0.1111
p.T218I	TCGA-EY-A1GK	UCEC	TCGA	DSGGDS	DEG_SCF_TRCP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons