DegronMD

Uniprot ID: Q7Z7A1

Source protein: Centriolin

Source gene: CNTRL

Class: DEG_APCC_DBOX_1

Location: 1205:1213

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9811

ASA_SCORE: 98.9667

COIL: 0.7644

CONS_SCORE: 0.59

DSS_SCORE: 0.5028

HELIX: 0.1867

FCONS_SCORE: 1.051

RIG_SCORE: 0.6887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1217N	TCGA-21-1079	LUSC	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	0.2222
p.D1217N	DO26846	LUSC	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	0.2222
p.P1204H	TCGA-37-3789	LUSC	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	0.3056
p.P1204H	DO26743	LUSC	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	0.3056
p.D1217Y	TCGA-AP-A1DK	UCEC	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	0.2222
p.D1217Y	DO42033	UCEC	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	0.2222
p.S1207N	TCGA-EE-A182	SKCM	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	0.5958
p.S1207N	DO37814	SKCM	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	0.5958
p.S1207N	SIDM00318	Kidney Carcinoma	GDSC	IRSGLHKLF	DEG_APCC_DBOX_1	0.5958
p.S1207N	ACH-000484	Kidney Cancer	CCLE	IRSGLHKLF	DEG_APCC_DBOX_1	0.5958
p.S1207N	VMRC-RCW	kidney	COSMIC	IRSGLHKLF	DEG_APCC_DBOX_1	0.5958
p.R1206M	TCGA-EE-A3AG	SKCM	TCGA	IRSGLHKLF	DEG_APCC_DBOX_1	0.8632
p.R1206M	DO37471	SKCM	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	0.8632
p.P1214A	DO223032	ESCA	ICGC	IRSGLHKLF	DEG_APCC_DBOX_1	0.3056
p.E1210K	MKN1	stomach	COSMIC	IRSGLHKLF	DEG_APCC_DBOX_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7A1	Centriolin	DEG_APCC_DBOX_1	1205:1213	IRSGLHKLF	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons