DegronMD

Uniprot ID: Q7Z7A1

Source protein: Centriolin

Source gene: CNTRL

Class: DEG_SPOP_SBC_1

Location: 2288:2292

E3 ligase: SPOP

DEGRON score: 0.8742

ASA_SCORE: 90.48

COIL: 0.6518

CONS_SCORE: 0.6078

DSS_SCORE: 0.5119

HELIX: 0.3274

FCONS_SCORE: 1.0302

RIG_SCORE: 0.7025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2296V	TCGA-D1-A103	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.2222
p.A2296V	DO42312	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.A2293T	TCGA-G3-A5SL	LIHC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.3056
p.A2293T	DO44978	LIHC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.D2282N	TCGA-TN-A7HL	HNSC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1667
p.D2282N	DO219080	HNSC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.L2287V	DO7042	CLLE	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.S2290R	DO46957	RECA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.8538
p.D2294Y	SIDM02059	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.2778
p.R2278S	SIDM01178	Other Solid Cancers	GDSC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R2278S	ACH-002200	Skin Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R2278S	SW962	vulva	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.A2283V	SIDM00373	Endometrial Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.A2283V	ACH-000974	Endometrial/Uterine Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.1944
p.A2283V	ACH-002026	Endometrial/Uterine Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.1944
p.A2283V	SNG-M	endometrium	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A519	Protein FAM170A	DEG_SPOP_SBC_1	51:55	VTSTS	SPOP	0.8827	More...
O75475	PC4 and SFRS1-interacting protein	DEG_SPOP_SBC_1	269:273	VTSTS	SPOP	0.9904	More...
P35638	DNA damage-inducible transcript 3 protein	DEG_SPOP_SBC_1	73:77	VTSTS	SPOP	0.8287	More...
Q01546	Keratin, type II cytoskeletal 2 oral	DEG_SPOP_SBC_1	512:516	VTSTS	SPOP	0.6377	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	804:808	VTSTS	SPOP	0.8927	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1557:1561	VTSTS	SPOP	0.8949	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	787:791	VTSTS	SPOP	0.9967	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1761:1765	VTSTS	SPOP	0.5627	More...
Q7Z7A1	Centriolin	DEG_SPOP_SBC_1	2288:2292	VTSTS	SPOP	0.8742	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1248:1252	VTSTS	SPOP	0.959	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1139:1143	VTSTS	SPOP	0.9584	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1376:1380	VTSTS	SPOP	0.995	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1801:1805	VTSTS	SPOP	0.9919	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2549:2553	VTSTS	SPOP	0.9158	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	1006:1010	VTSTS	SPOP	0.8996	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	870:874	VTSTS	SPOP	0.9347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons