DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VTSTS
Uniprot ID:
Q96T58
Source protein:
Msx2-interacting protein
Source gene:
SPEN
Class:
DEG_SPOP_SBC_1
Location:
2549:2553
E3 ligase:
SPOP
DEGRON score:
0.9158
ASA_SCORE:
90.3
COIL:
0.9554
CONS_SCORE:
0.3722
DSS_SCORE:
0.3285
HELIX:
0.016
FCONS_SCORE:
0.91
RIG_SCORE:
0.7199
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V2562A
TCGA-BR-8680
STAD
TCGA
VTSTS
DEG_SPOP_SBC_1
0.0833
p.V2562A
DO47769
STAD
ICGC
VTSTS
DEG_SPOP_SBC_1
0.0833
p.P2541L
TCGA-DA-A1I0
SKCM
TCGA
VTSTS
DEG_SPOP_SBC_1
0.1111
p.P2541L
DO37719
SKCM
ICGC
VTSTS
DEG_SPOP_SBC_1
0.1111
p.P2541H
TCGA-DU-6392
LGG
TCGA
VTSTS
DEG_SPOP_SBC_1
0.1111
p.P2541H
DO22237
LGG
ICGC
VTSTS
DEG_SPOP_SBC_1
0.1111
p.S2553G
TCGA-EE-A29S
SKCM
TCGA
VTSTS
DEG_SPOP_SBC_1
0.6993
p.S2553G
DO37936
SKCM
ICGC
VTSTS
DEG_SPOP_SBC_1
0.6993
p.S2553G
SIDM00454
Rhabdomyosarcoma
GDSC
VTSTS
DEG_SPOP_SBC_1
0.6993
p.S2553G
SIDM01072
Squamous Cell Lung Carcinoma
GDSC
VTSTS
DEG_SPOP_SBC_1
0.6993
p.E2560K
SIDM00997
Thyroid Gland Carcinoma
GDSC
VTSTS
DEG_SPOP_SBC_1
0.1389
p.E2560K
SIDM00970
Bladder Carcinoma
GDSC
VTSTS
DEG_SPOP_SBC_1
0.1389
p.E2560K
ACH-002235
Bladder Cancer
CCLE
VTSTS
DEG_SPOP_SBC_1
0.1389
p.E2560K
DSH1
urinary_tract
COSMIC
VTSTS
DEG_SPOP_SBC_1
0.1389
p.E2560K
8305C
thyroid
COSMIC
VTSTS
DEG_SPOP_SBC_1
0.1389
p.A2546V
SIDM00217
Colorectal Carcinoma
GDSC
VTSTS
DEG_SPOP_SBC_1
0.25
p.A2546V
ACH-000999
Colon/Colorectal Cancer
CCLE
VTSTS
DEG_SPOP_SBC_1
0.25
p.A2546V
SNU-1040
large_intestine
COSMIC
VTSTS
DEG_SPOP_SBC_1
0.25
p.P2561S
SIDM00150
Colorectal Carcinoma
GDSC
VTSTS
DEG_SPOP_SBC_1
0.1111
p.P2561S
ACH-000969
Colon/Colorectal Cancer
CCLE
VTSTS
DEG_SPOP_SBC_1
0.1111
p.P2561S
KM12
large_intestine
COSMIC
VTSTS
DEG_SPOP_SBC_1
0.1111
p.P2561A
SIDM01473
Plasma Cell Myeloma
GDSC
VTSTS
DEG_SPOP_SBC_1
0.1111
p.P2561A
ACH-000541
Myeloma
CCLE
VTSTS
DEG_SPOP_SBC_1
0.1111
Drug responses associated with SPEN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1A519
Protein FAM170A
DEG_SPOP_SBC_1
51:55
VTSTS
SPOP
0.8827
More...
O75475
PC4 and SFRS1-interacting protein
DEG_SPOP_SBC_1
269:273
VTSTS
SPOP
0.9904
More...
P35638
DNA damage-inducible transcript 3 protein
DEG_SPOP_SBC_1
73:77
VTSTS
SPOP
0.8287
More...
Q01546
Keratin, type II cytoskeletal 2 oral
DEG_SPOP_SBC_1
512:516
VTSTS
SPOP
0.6377
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
804:808
VTSTS
SPOP
0.8927
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1557:1561
VTSTS
SPOP
0.8949
More...
Q14966
Zinc finger protein 638
DEG_SPOP_SBC_1
787:791
VTSTS
SPOP
0.9967
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
1761:1765
VTSTS
SPOP
0.5627
More...
Q7Z7A1
Centriolin
DEG_SPOP_SBC_1
2288:2292
VTSTS
SPOP
0.8742
More...
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
1248:1252
VTSTS
SPOP
0.959
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1139:1143
VTSTS
SPOP
0.9584
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1376:1380
VTSTS
SPOP
0.995
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1801:1805
VTSTS
SPOP
0.9919
More...
Q96T58
Msx2-interacting protein
DEG_SPOP_SBC_1
2549:2553
VTSTS
SPOP
0.9158
More...
Q9H2X6
Homeodomain-interacting protein kinase 2
DEG_SPOP_SBC_1
1006:1010
VTSTS
SPOP
0.8996
More...
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SPOP_SBC_1
870:874
VTSTS
SPOP
0.9347
More...