DegronMD - O75475(PSIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L264V	TCGA-B5-A1MR	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.L264V	DO41758	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.K70Q	TCGA-BS-A0UF	UCEC	TCGA	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation substituting flanking lysine	0.25
p.K70Q	DO41488	UCEC	ICGC	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation substituting flanking lysine	0.25
p.D274N	TCGA-BS-A0UV	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.D274N	DO42793	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.T50I	TCGA-BS-A0UV	UCEC	TCGA	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.T50I	DO42793	UCEC	ICGC	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.K56N	TCGA-D3-A3C6	SKCM	TCGA	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.K56N	DO37507	SKCM	ICGC	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.S259T	DO7388	CLLE	ICGC	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.0556
p.T270S	DO230309	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.7116
p.G54E	DO23206	LINC	ICGC	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.K56R	DO50664	ORCA	ICGC	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.E278G	SIDM00581	Glioblastoma	GDSC	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.E278G	GB-1	central nervous system	COSMIC	VTSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.F59C	SIDM00118	Colorectal Carcinoma	GDSC	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.5996
p.F59C	ACH-001081	Colon/Colorectal Cancer	CCLE	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.5996
p.F59C	HCC2998	large intestine	COSMIC	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.5996
p.K65M	ACH-001068	Lymphoma	CCLE	IFPYSE	LIG_APCC_ABBA_1	58:63	Mutation blocking ubiquitination signal	0.7222

Kaplan plot for PSIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSIP1

UniProt ID: O75475

Entrez ID: 11168

Protein name: PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSIP1 in