DegronMD

Uniprot ID: O75475

Source protein: PC4 and SFRS1-interacting protein

Source gene: PSIP1

Class: DEG_SPOP_SBC_1

Location: 269:273

E3 ligase: SPOP

DEGRON score: 0.9904

ASA_SCORE: 90.48

COIL: 0.929

CONS_SCORE: 0.4448

DSS_SCORE: 0.6516

HELIX: 0.0298

FCONS_SCORE: 0.9964

RIG_SCORE: 0.6158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L264V	TCGA-B5-A1MR	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1944
p.L264V	DO41758	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.D274N	TCGA-BS-A0UV	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.3056
p.D274N	DO42793	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.S259T	DO7388	CLLE	ICGC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.T270S	DO230309	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7116
p.E278G	SIDM00581	Glioblastoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.E278G	GB-1	central_nervous_system	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A519	Protein FAM170A	DEG_SPOP_SBC_1	51:55	VTSTS	SPOP	0.8827	More...
O75475	PC4 and SFRS1-interacting protein	DEG_SPOP_SBC_1	269:273	VTSTS	SPOP	0.9904	More...
P35638	DNA damage-inducible transcript 3 protein	DEG_SPOP_SBC_1	73:77	VTSTS	SPOP	0.8287	More...
Q01546	Keratin, type II cytoskeletal 2 oral	DEG_SPOP_SBC_1	512:516	VTSTS	SPOP	0.6377	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	804:808	VTSTS	SPOP	0.8927	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1557:1561	VTSTS	SPOP	0.8949	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	787:791	VTSTS	SPOP	0.9967	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1761:1765	VTSTS	SPOP	0.5627	More...
Q7Z7A1	Centriolin	DEG_SPOP_SBC_1	2288:2292	VTSTS	SPOP	0.8742	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1248:1252	VTSTS	SPOP	0.959	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1139:1143	VTSTS	SPOP	0.9584	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1376:1380	VTSTS	SPOP	0.995	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1801:1805	VTSTS	SPOP	0.9919	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2549:2553	VTSTS	SPOP	0.9158	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	1006:1010	VTSTS	SPOP	0.8996	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	870:874	VTSTS	SPOP	0.9347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons