DegronMD - Q9H2X6(HIPK2)

FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850}. View more >>

GO - Biological processes (BP): adult walking behavior [GO:0007628]; anterior/posterior pattern specification [GO:0009952]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; erythrocyte differentiation [GO:0030218]; eye development [GO:0001654]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; transforming growth factor beta receptor signaling pathway [GO:0007179]; voluntary musculoskeletal movement [GO:0050882] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E897G	TCGA-02-2483	GBM	TCGA	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1667
p.E897G	DO12352	GBM	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1667
p.F568L	TCGA-06-5416	GBM	TCGA	APSTS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1944
p.F568L	DO10880	GBM	ICGC	APSTS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1944
p.V790M	TCGA-19-5956	GBM	TCGA	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1944
p.V790M	TCGA-AX-A06F	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1944
p.V790M	DO13863	GBM	ICGC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1944
p.V790M	DO229018	LICA	ICGC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1944
p.V790M	DO41752	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1944
p.R792L	TCGA-44-4112	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.25
p.R792L	DO26032	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.25
p.A161S	TCGA-44-6774	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1944
p.A161S	DO25000	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1944
p.S800Y	TCGA-55-6979	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.3056
p.S800Y	DO24110	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.3056
p.E898K	TCGA-A3-3378	KIRC	TCGA	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1944
p.P878L	TCGA-A5-A0VQ	UCEC	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation altering degron motif	0.6471
p.P878L	DO42113	UCEC	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation altering degron motif	0.6471
p.E896D	TCGA-AA-3492	COAD	TCGA	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.E896D	TCGA-EY-A215	UCEC	TCGA	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.E896D	DO8224	COAD	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.E896D	DO233109	GACA	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.E896D	DO42665	UCEC	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.R841H	TCGA-AA-A02O	COAD	TCGA	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.25
p.R841H	TCGA-AA-A02O	COAD	TCGA	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.0833
p.R841H	DO9226	COAD	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.25
p.R841H	DO9226	COAD	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.0833
p.R841H	DO229039	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.25
p.R841H	DO229039	LICA	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.0833
p.T889A	TCGA-AO-A128	BRCA	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1944
p.T889A	DO5326	BRCA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1944
p.V94M	TCGA-AR-A2LN	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.V94M	DO4197	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.V94M	DO223068	ESCA	ICGC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.A98T	TCGA-AU-6004	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.7139
p.A98T	DO7780	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.7139
p.R870W	TCGA-AX-A3FT	UCEC	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1389
p.R870W	TCGA-AX-A3FT	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.R870W	DO40801	UCEC	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1389
p.R870W	DO40801	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.P849L	TCGA-BG-A0YV	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.3056
p.P849L	DO41428	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.3056
p.D895G	TCGA-BR-4361	STAD	TCGA	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1111
p.D895G	DO38887	STAD	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1111
p.I888N	TCGA-BR-4361	STAD	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.2222
p.I888N	DO38887	STAD	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.2222
p.R841C	TCGA-CV-A6K1	HNSC	TCGA	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.25
p.R841C	TCGA-CV-A6K1	HNSC	TCGA	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.0833
p.R841C	DO234204	ESAD	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.25
p.R841C	DO234204	ESAD	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.0833
p.R841C	DO52078	HNSC	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.25
p.R841C	DO52078	HNSC	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.0833
p.V95A	TCGA-D1-A167	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.25
p.V95A	DO40978	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.25
p.S52G	TCGA-D1-A174	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.S52G	DO40900	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0556
p.P72L	TCGA-DD-A4NO	LIHC	TCGA	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1667
p.P72L	DO45013	LIHC	ICGC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1667
p.S180C	TCGA-E7-A3Y1	BLCA	TCGA	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.S180C	DO528	BLCA	ICGC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.V1006M	TCGA-EC-A1QX	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	1006:1010	Mutation altering degron motif	0.7208
p.V1006M	DO42592	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	1006:1010	Mutation altering degron motif	0.7208
p.S54C	TCGA-ED-A7PZ	LIHC	TCGA	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1111
p.S54C	DO48532	LIHC	ICGC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1111
p.Q53H	TCGA-ED-A7PZ	LIHC	TCGA	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.Q53H	TCGA-L5-A8NQ	ESCA	TCGA	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.Q53H	DO48532	LIHC	ICGC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.0833
p.S577P	TCGA-FI-A2D5	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6752
p.S577P	DO41331	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6752
p.A171T	TCGA-FP-A4BE	STAD	TCGA	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.A171T	DO233898	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.A171T	DO48016	STAD	ICGC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.C857S	TCGA-LG-A9QC	LIHC	TCGA	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.25
p.C857S	TCGA-LG-A9QC	LIHC	TCGA	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.C857S	DO49701	LIHC	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.25
p.C857S	DO49701	LIHC	ICGC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.P72Q	TCGA-QS-A5YR	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1667
p.P72Q	DO50081	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1667
p.P62Q	TCGA-VR-AA7B	ESCA	TCGA	PATTT	DEG_SPOP_SBC_1	62:66	Mutation altering degron motif	0.7035
p.T570M	DO218535	BTCA	ICGC	APSTS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.25
p.S178P	DO233179	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.S797R	DO233242	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation altering degron motif	0.7427
p.G1011S	DO233259	GACA	ICGC	VTSTS	DEG_SPOP_SBC_1	1006:1010	Mutation rewiring degron network	0.3056
p.S882G	DO233259	GACA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation altering degron motif	0.6993
p.G892E	DO233224	GACA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1111
p.G160R	DO233941	GACA	ICGC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1667
p.G160R	SIDM00449	B-Lymphoblastic Leukemia	GDSC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1667
p.G160R	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1667
p.A903V	DO233903	GACA	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation altering degron motif	0.5825
p.S891C	DO228212	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1389
p.N585K	DO228948	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1111
p.T1009N	DO228948	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	1006:1010	Mutation altering degron motif	0.7055
p.P839T	DO228952	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.3056
p.T894K	DO228952	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.0556
p.T894K	DO228952	LICA	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.0833
p.S891R	DO229015	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1389
p.S900Y	DO229029	LICA	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.25
p.P878T	DO229029	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation altering degron motif	0.5919
p.L899I	DO229028	LICA	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2222
p.A824D	DO229027	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.0556
p.S176R	DO229038	LICA	ICGC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1667
p.H902Q	DO229037	LICA	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.3056
p.E899K	DO50904	LICA	ICGC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.2222
p.T570A	DO231830	LINC	ICGC	APSTS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.25
p.D861H	DO45037	LINC	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.1389
p.D861H	DO45037	LINC	ICGC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.3056
p.P878S	DO222536	MELA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation altering degron motif	0.5641
p.V887A	DO222567	MELA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.25
p.D861N	DO46360	OV	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.1389
p.D861N	DO46360	OV	ICGC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.3056
p.T866A	DO229446	SKCA	ICGC	VASST	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7139
p.M844I	DO229259	THCA	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.1667
p.M844I	DO229259	THCA	ICGC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.1667
p.P795S	DO229272	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation altering degron motif	0.6752
p.I825M	DO229540	UTCA	ICGC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.0833
p.V67I	SIDM00789	Colorectal Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.3056
p.V67I	HCT-15	large intestine	COSMIC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.3056
p.H807R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1111
p.H807R	ACH-002256	Leukemia	CCLE	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1111
p.H807R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1111
p.K805R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation blocking ubiquitination signal	0.6111
p.K805R	ACH-002256	Leukemia	CCLE	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation blocking ubiquitination signal	0.6111
p.K805R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation blocking ubiquitination signal	0.6111
p.S1002Y	SIDM00799	Glioblastoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1006:1010	Mutation rewiring degron network	0.2222
p.S1002Y	ACH-000558	Brain Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	1006:1010	Mutation rewiring degron network	0.2222
p.S1002Y	A172	central nervous system	COSMIC	VTSTS	DEG_SPOP_SBC_1	1006:1010	Mutation rewiring degron network	0.2222
p.R868W	SIDM00351	Oral Cavity Carcinoma	GDSC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.0833
p.R868W	SIDM00351	Oral Cavity Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.R868W	SIDM01782	Oral Cavity Carcinoma	GDSC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.0833
p.R868W	SIDM01782	Oral Cavity Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.R868W	SAS	upper aerodigestive tract	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.0833
p.R868W	SAS	upper aerodigestive tract	COSMIC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.R833C	SIDM00878	Breast Carcinoma	GDSC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.3056
p.R833C	ACH-000930	Breast Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.3056
p.R833C	HCC1569	breast	COSMIC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.3056
p.V94E	SIDM01045	Endometrial Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.V94E	ACH-000978	Endometrial/Uterine Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.V94E	EN	endometrium	COSMIC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.E896K	SIDM00217	Colorectal Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.E896K	ACH-000999	Colon/Colorectal Cancer	CCLE	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.E896K	SNU-1040	large intestine	COSMIC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.N914K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.N914K	ACH-001127	Leukemia	CCLE	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.N914K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.I875V	SIDM00864	Cervical Carcinoma	GDSC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.2778
p.I875V	SIDM00864	Cervical Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.0833
p.I875V	ACH-001341	Cervical Cancer	CCLE	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.2778
p.I875V	ACH-001341	Cervical Cancer	CCLE	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.0833
p.I875V	DoTc2-4510	cervix	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.2778
p.I875V	DoTc2-4510	cervix	COSMIC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.0833
p.R792W	SIDM00783	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.25
p.R792W	ACH-000971	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.25
p.R792W	HCT-116	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.25
p.L108F	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1667
p.L108F	ACH-000937	Leukemia	CCLE	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1667
p.L108F	PF-382	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1667
p.N157D	SIDM01617	Endometrial Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.N157D	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.R792Q	ACH-000872	Lung Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.25
p.I57T	ACH-000908	Gastric Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.1944
p.T894A	ACH-001063	Ovarian Cancer	CCLE	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.0556
p.T894A	ACH-001063	Ovarian Cancer	CCLE	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.0833
p.V862M	ACH-001518	Endometrial/Uterine Cancer	CCLE	VASST	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7208
p.T576M	ACH-001521	Skin Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7423
p.T576S	ACH-001521	Skin Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6005
p.R914C	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	APTST	DEG_SPOP_SBC_1	903:907	Mutation rewiring degron network	0.1389
p.K798R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation altering degron motif	0.7237
p.N887K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.25
p.R834C	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation altering degron motif	0.8301
p.I848V	DoTc2-4510	cervix	COSMIC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation blocking phosphorylation signal	0.5
p.I848V	DoTc2-4510	cervix	COSMIC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation blocking phosphorylation signal	0.7222
p.N807K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1111
p.L101F	PF-382	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	98:102	Mutation altering degron motif	0.6981
p.S878T	NCI-H378	lung	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation altering degron motif	0.7116
p.V60I	HCT-15	large intestine	COSMIC	PATTT	DEG_SPOP_SBC_1	62:66	Mutation rewiring degron network	0.2778
p.R785W	HCT-116	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.0556
p.R841W	SAS	upper aerodigestive tract	COSMIC	VKENT	DEG_APCC_KENBOX_2	834:838	Mutation rewiring degron network	0.25
p.R841W	SAS	upper aerodigestive tract	COSMIC	ACSTS	DEG_SPOP_SBC_1	850:854	Mutation rewiring degron network	0.0833
p.R806C	HCC1569	breast	COSMIC	PTSTT	DEG_SPOP_SBC_1	795:799	Mutation rewiring degron network	0.1389
p.E869K	SNU-1040	large intestine	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	877:884	Mutation rewiring degron network	0.1111
p.E869K	SNU-1040	large intestine	COSMIC	VASST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIPK2

UniProt ID: Q9H2X6

Entrez ID: 28996

Protein name: Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HIPK2 in