DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_SPOP_SBC_1

Location: 573:577

E3 ligase: SPOP

DEGRON score: 0.9899

ASA_SCORE: 71.76

COIL: 0.9268

CONS_SCORE: 0.3839

DSS_SCORE: 0.3696

HELIX: 0.0392

FCONS_SCORE: 1.0282

RIG_SCORE: 0.7295

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F568L	TCGA-06-5416	GBM	TCGA	APSTS	DEG_SPOP_SBC_1	0.1944
p.F568L	DO10880	GBM	ICGC	APSTS	DEG_SPOP_SBC_1	0.1944
p.S577P	TCGA-FI-A2D5	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	0.6752
p.S577P	DO41331	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	0.6752
p.T570M	DO218535	BTCA	ICGC	APSTS	DEG_SPOP_SBC_1	0.25
p.N585K	DO228948	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	0.1111
p.T570A	DO231830	LINC	ICGC	APSTS	DEG_SPOP_SBC_1	0.25
p.T576M	ACH-001521	Skin Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.7423
p.T576S	ACH-001521	Skin Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.6005

Drug responses associated with HIPK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E136D (No)	GDSC	PI-103	186.6479
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.I227T (No)	GDSC	PI-103	1.081
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1184V (No)	GDSC	PI-103	0.1231
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM01045	UCEC\|endometrium	p.L59fs*56 (No)	GDSC	PI-103	3.7811
SIDM00499	PRAD\|prostate	p.G45D (No)	GDSC	PI-103	0.3537
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (No)	GDSC	PI-103	0.1685
SIDM00108	SKCM\|melanoma	p.H322Q (No)	GDSC	PI-103	2.1752
SIDM00351	HNSC\|head_and_neck	p.R868W (No)	GDSC	PI-103	1.0036
SIDM00976	SKCM\|melanoma	p.G348R (No)	GDSC	PI-103	0.2229
SIDM00045	STAD\|stomach	p.C658F (No)	GDSC	PI-103	0.7557
SIDM01107	SKCM\|melanoma	p.T602P (No)	GDSC	PI-103	57.4273
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.S142N (No)	GDSC	PI-103	0.2031
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.H760R (No)	GDSC	PI-103	2.0651
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00377	UNCLASSIFIED\|uterus	p.H540R (No)	GDSC	PI-103	2.6284
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.A624V (No)	GDSC	PI-103	0.0783
SIDM01045	UCEC\|endometrium	p.V94E (No)	GDSC	PI-103	3.7811
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00864	CESC\|cervix	p.I875V (No)	GDSC	PI-103	23.1182
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.R433S (No)	GDSC	PI-103	131.0205
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (No)	GDSC	PI-103	1.8634
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00596	UCEC\|endometrium	p.R498Q (No)	GDSC	PI-103	22.6646
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00955	SKCM\|melanoma	p.T1022N (No)	GDSC	PI-103	14.8056
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I33V (No)	GDSC	PI-103	0.0974
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00149	SKCM\|melanoma	p.M635I (No)	GDSC	PI-103	3.9173
SIDM00545	SKCM\|melanoma	p.R1056Q (No)	GDSC	PI-103	9.7833
SIDM00545	SKCM\|melanoma	p.H524Y (No)	GDSC	PI-103	9.7833
SIDM00114	MESO\|mesothelioma	p.L716I (No)	GDSC	PI-103	6.8017
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S317I (No)	GDSC	PI-103	17.6642
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F500V (No)	GDSC	PI-103	1.0649
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y468N (No)	GDSC	PI-103	1.0649
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00799	GBM\|glioma	p.S1002Y (No)	GDSC	PI-103	54.1746
SIDM00496	THCA\|thyroid	p.Q747K (No)	GDSC	PI-103	0.4742
SIDM00878	BRCA\|breast	p.R833C (No)	GDSC	PI-103	0.1835

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	DEG_SPOP_SBC_1	2270:2274	APSTS	SPOP	0.9988	More...
O60721	Sodium/potassium/calcium exchanger 1	DEG_SPOP_SBC_1	374:378	APSTS	SPOP	0.895	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	760:764	APSTS	SPOP	0.9536	More...
O75962	Triple functional domain protein	DEG_SPOP_SBC_1	2330:2334	APSTS	SPOP	0.9832	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	282:286	APSTS	SPOP	0.9986	More...
P20333	Tumor necrosis factor receptor superfamily member 1B	DEG_SPOP_SBC_1	236:240	APSTS	SPOP	0.8766	More...
P23193	Transcription elongation factor A protein 1	DEG_SPOP_SBC_1	133:137	APSTS	SPOP	0.9964	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	26:30	APSTS	SPOP	0.9904	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	962:966	APSTS	SPOP	0.9991	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	762:766	APSTS	SPOP	0.8531	More...
Q14123	Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	DEG_SPOP_SBC_1	641:645	APSTS	SPOP	0.9831	More...
Q15007	Pre-mRNA-splicing regulator WTAP	DEG_SPOP_SBC_1	248:252	APSTS	SPOP	0.9316	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	108:112	APSTS	SPOP	0.9976	More...
Q66K74	Microtubule-associated protein 1S	DEG_SPOP_SBC_1	565:569	APSTS	SPOP	0.972	More...
Q6IQ49	Replication stress response regulator SDE2	DEG_SPOP_SBC_1	238:242	APSTS	SPOP	0.999	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2700:2704	APSTS	SPOP	0.9449	More...
Q86V42	Protein FAM124A	DEG_SPOP_SBC_1	500:504	APSTS	SPOP	0.9876	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	374:378	APSTS	SPOP	0.9854	More...
Q8NCP5	Zinc finger and BTB domain-containing protein 44	DEG_SPOP_SBC_1	381:385	APSTS	SPOP	0.9707	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5164:5168	APSTS	SPOP	0.9867	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_SPOP_SBC_1	460:464	APSTS	SPOP	0.8719	More...
Q96MG7	Non-structural maintenance of chromosomes element 3 homolog	DEG_SPOP_SBC_1	47:51	APSTS	SPOP	0.9985	More...
Q96N64	PWWP domain-containing protein 2A	DEG_SPOP_SBC_1	613:617	APSTS	SPOP	0.9195	More...
Q96T37	RNA-binding protein 15	DEG_SPOP_SBC_1	753:757	APSTS	SPOP	0.9492	More...
Q9H1K4	Mitochondrial glutamate carrier 2	DEG_SPOP_SBC_1	146:150	APSTS	SPOP	0.6475	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	573:577	APSTS	SPOP	0.9899	More...
Q9H8N7	Zinc finger protein 395	DEG_SPOP_SBC_1	64:68	APSTS	SPOP	0.9883	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	114:118	APSTS	SPOP	0.8965	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	1162:1166	APSTS	SPOP	0.9964	More...
P0C7U3	Probable palmitoyltransferase ZDHHC11B	DEG_SPOP_SBC_1	346:350	APSTS	SPOP	0.9986	More...
Q5FWE3	Proline-rich transmembrane protein 3	DEG_SPOP_SBC_1	411:415	APSTS	SPOP	0.9643	More...
Q8NCU7	C2 calcium-dependent domain-containing protein 4A	DEG_SPOP_SBC_1	226:230	APSTS	SPOP	0.999	More...
Q9BUT9	MAPK regulated corepressor interacting protein 2	DEG_SPOP_SBC_1	76:80	APSTS	SPOP	0.9973	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	85:89	APSTS	SPOP	0.9092	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9733	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9531	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1842:1846	APSTS	SPOP	0.9477	More...
Q9H8U3	AN1-type zinc finger protein 3	DEG_SPOP_SBC_1	49:53	APSTS	SPOP	0.8073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTS

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of APSTS