DegronMD - Q5FWE3(PRRT3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P407S	TCGA-06-5856	GBM	TCGA	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2222
p.P407S	DO13456	GBM	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2222
p.L931I	TCGA-55-6981	LUAD	TCGA	WRHGLSSVD	DEG_APCC_DBOX_1	919:927	Mutation rewiring degron network	0.2222
p.L931I	DO24265	LUAD	ICGC	WRHGLSSVD	DEG_APCC_DBOX_1	919:927	Mutation rewiring degron network	0.2222
p.A67D	TCGA-A5-A0G1	UCEC	TCGA	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.A67D	DO42472	UCEC	ICGC	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.R416C	TCGA-CM-4743	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.3056
p.R416C	DO8103	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.3056
p.S50Y	TCGA-EI-6917	READ	TCGA	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.S50Y	DO36881	READ	ICGC	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.S50F	TCGA-F7-8489	HNSC	TCGA	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.S50F	DO14319	HNSC	ICGC	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.R920P	DO223536	CLLE	ICGC	WRHGLSSVD	DEG_APCC_DBOX_1	919:927	Mutation altering degron motif	0.7512
p.P62L	DO227844	COCA	ICGC	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6471
p.E418D	DO234219	ESAD	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.N72K	DO228974	LICA	ICGC	FDVFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.S936R	DO228985	LICA	ICGC	WRHGLSSVD	DEG_APCC_DBOX_1	919:927	Mutation rewiring degron network	0.0833
p.C404F	DO32183	OV	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.S413L	DO229181	THCA	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7667
p.R827Q	DO229253	THCA	ICGC	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation rewiring degron network	0.1944
p.C834F	DO229272	THCA	ICGC	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation altering degron motif	0.5996
p.A847T	DO229242	THCA	ICGC	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation rewiring degron network	0.1389
p.T423A	DO229084	THCA	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.A417V	DO40978	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.G401A	DO41193	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0556
p.R827L	SIDM00995	Other Solid Cancers	GDSC	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation rewiring degron network	0.1944
p.R827L	ACH-001328	Skin Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation rewiring degron network	0.1944
p.G418S	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.G418S	ACH-000408	Esophageal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.W916R	SIDM00793	Burkitt's Lymphoma	GDSC	WRHGLSSVD	DEG_APCC_DBOX_1	919:927	Mutation rewiring degron network	0.25
p.G910V	ACH-000610	Lung Cancer	CCLE	WRHGLSSVD	DEG_APCC_DBOX_1	919:927	Mutation rewiring degron network	0.0833
p.E823V	ACH-000674	Gastric Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation rewiring degron network	0.0833
p.G846S	ACH-000871	Lung Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation rewiring degron network	0.1667
p.G846S	ACH-001408	Bladder Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	832:840	Mutation rewiring degron network	0.1667
p.P408T	ACH-000961	Endometrial/Uterine Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRT3

UniProt ID: Q5FWE3

Entrez ID: 285368

Protein name: Proline-rich transmembrane protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRT3 in