DegronMD

Uniprot ID: Q5FWE3

Source protein: Proline-rich transmembrane protein 3

Source gene: PRRT3

Class: DEG_APCC_DBOX_1

Location: 832:840

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9628

ASA_SCORE: 61.7444

COIL: 0.8052

CONS_SCORE: 0.8986

DSS_SCORE: 0.4406

HELIX: 0.1064

FCONS_SCORE: 0.9729

RIG_SCORE: 0.7192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R827Q	DO229253	THCA	ICGC	QRCGLRGLA	DEG_APCC_DBOX_1	0.1944
p.C834F	DO229272	THCA	ICGC	QRCGLRGLA	DEG_APCC_DBOX_1	0.5996
p.A847T	DO229242	THCA	ICGC	QRCGLRGLA	DEG_APCC_DBOX_1	0.1389
p.R827L	SIDM00995	Other Solid Cancers	GDSC	QRCGLRGLA	DEG_APCC_DBOX_1	0.1944
p.R827L	ACH-001328	Skin Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	0.1944
p.E823V	ACH-000674	Gastric Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	0.0833
p.G846S	ACH-000871	Lung Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	0.1667
p.G846S	ACH-001408	Bladder Cancer	CCLE	QRCGLRGLA	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FWE3	Proline-rich transmembrane protein 3	DEG_APCC_DBOX_1	832:840	QRCGLRGLA	APC,CDC20,FZR1	0.9628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons