DegronMD

Uniprot ID: Q5FWE3

Source protein: Proline-rich transmembrane protein 3

Source gene: PRRT3

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5103

ASA_SCORE: 90.0167

COIL: 0.8517

CONS_SCORE: 0.6719

DSS_SCORE: 0.7096

HELIX: 0.0865

FCONS_SCORE: 1.1696

RIG_SCORE: 0.6849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A67D	TCGA-A5-A0G1	UCEC	TCGA	FDVFPE	LIG_APCC_ABBA_1	0.2222
p.A67D	DO42472	UCEC	ICGC	FDVFPE	LIG_APCC_ABBA_1	0.2222
p.S50Y	TCGA-EI-6917	READ	TCGA	FDVFPE	LIG_APCC_ABBA_1	0.1111
p.S50Y	DO36881	READ	ICGC	FDVFPE	LIG_APCC_ABBA_1	0.1111
p.S50F	TCGA-F7-8489	HNSC	TCGA	FDVFPE	LIG_APCC_ABBA_1	0.1111
p.S50F	DO14319	HNSC	ICGC	FDVFPE	LIG_APCC_ABBA_1	0.1111
p.P62L	DO227844	COCA	ICGC	FDVFPE	LIG_APCC_ABBA_1	0.6471
p.N72K	DO228974	LICA	ICGC	FDVFPE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FWE3	Proline-rich transmembrane protein 3	LIG_APCC_ABBA_1	58:63	FDVFPE	APC,CDC20,FZR1	0.5103	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons