DegronMD

Uniprot ID: Q5FWE3

Source protein: Proline-rich transmembrane protein 3

Source gene: PRRT3

Class: DEG_APCC_DBOX_1

Location: 919:927

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9324

ASA_SCORE: 76.4444

COIL: 0.7902

CONS_SCORE: 1

DSS_SCORE: 0.302

HELIX: 0.1167

FCONS_SCORE: 1.0148

RIG_SCORE: 0.7128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L931I	TCGA-55-6981	LUAD	TCGA	WRHGLSSVD	DEG_APCC_DBOX_1	0.2222
p.L931I	DO24265	LUAD	ICGC	WRHGLSSVD	DEG_APCC_DBOX_1	0.2222
p.R920P	DO223536	CLLE	ICGC	WRHGLSSVD	DEG_APCC_DBOX_1	0.7512
p.S936R	DO228985	LICA	ICGC	WRHGLSSVD	DEG_APCC_DBOX_1	0.0833
p.W916R	SIDM00793	Burkitt's Lymphoma	GDSC	WRHGLSSVD	DEG_APCC_DBOX_1	0.25
p.G910V	ACH-000610	Lung Cancer	CCLE	WRHGLSSVD	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FWE3	Proline-rich transmembrane protein 3	DEG_APCC_DBOX_1	919:927	WRHGLSSVD	APC,CDC20,FZR1	0.9324	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons