DegronMD - Q96T37(RBM15)

FUNCTION: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K764E	TCGA-06-1802	GBM	TCGA	APSTS	DEG_SPOP_SBC_1	753:757	Mutation substituting flanking lysine	0.25
p.K764E	DO12100	GBM	ICGC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation substituting flanking lysine	0.25
p.K87N	TCGA-AJ-A5DW	UCEC	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation substituting flanking lysine	0.2222
p.K87N	DO50075	UCEC	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation substituting flanking lysine	0.2222
p.R748C	TCGA-CM-6171	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.R748C	DO8151	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.1944
p.G297C	TCGA-D7-A4YV	STAD	TCGA	DYR	CBL_MET	304:306	Mutation rewiring degron network	0.1389
p.G297C	DO47777	STAD	ICGC	DYR	CBL_MET	304:306	Mutation rewiring degron network	0.1389
p.S749C	TCGA-D8-A1JA	BRCA	TCGA	APSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.S749C	DO2819	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2222
p.S105N	TCGA-DK-A1AA	BLCA	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation blocking phosphorylation signal	0.6667
p.S105N	DO548	BLCA	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation blocking phosphorylation signal	0.6667
p.D101N	TCGA-EO-A22U	UCEC	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation altering degron motif	0.6932
p.D101N	DO43755	UCEC	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation altering degron motif	0.6932
p.E111D	TCGA-EO-A22X	UCEC	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation rewiring degron network	0.0556
p.E111D	DO43907	UCEC	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation rewiring degron network	0.0556
p.D89N	TCGA-KQ-A41S	BLCA	TCGA	DSGGGS	DEG_SCF_TRCP1_1	89:94	Mutation altering degron motif	0.6932
p.D89N	DO223593	BLCA	ICGC	DSGGGS	DEG_SCF_TRCP1_1	89:94	Mutation altering degron motif	0.6932
p.R314P	DO48380	BLCA	ICGC	DYR	CBL_MET	304:306	Mutation rewiring degron network	0.1111
p.G297V	DO225126	BRCA	ICGC	DYR	CBL_MET	304:306	Mutation rewiring degron network	0.1389
p.G92S	DO223460	CLLE	ICGC	DSGGGS	DEG_SCF_TRCP1_1	89:94	Mutation altering degron motif	0.5882
p.G296D	DO44674	LICA	ICGC	DYR	CBL_MET	304:306	Mutation rewiring degron network	0.1111
p.S765F	DO229177	LMS	ICGC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation blocking phosphorylation signal	0.5556
p.S757G	DO222420	MELA	ICGC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation altering degron motif	0.6993
p.G297D	DO224575	PACA	ICGC	DYR	CBL_MET	304:306	Mutation rewiring degron network	0.1389
p.A759V	SIDM00938	Breast Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2778
p.A759V	ACH-000902	Breast Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2778
p.A759V	CAL-148	breast	COSMIC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation rewiring degron network	0.2778
p.S765Y	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation blocking phosphorylation signal	0.5556
p.S765Y	ACH-000888	Lung Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	753:757	Mutation blocking phosphorylation signal	0.5556
p.S765Y	NCI-H1793	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	753:757	Mutation blocking phosphorylation signal	0.5556
p.S103F	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGGGS	DEG_SCF_TRCP1_1	89:94	Mutation blocking phosphorylation signal	0.5278
p.S103F	ACH-000969	Colon/Colorectal Cancer	CCLE	RRSLHLD	LIG_APCC_ABBAyCdc20_2	95:101	Mutation blocking phosphorylation signal	0.7222
p.S94A	ACH-001047	Lung Cancer	CCLE	DSGGGS	DEG_SCF_TRCP1_1	89:94	Mutation altering degron motif	0.7588

Kaplan plot for RBM15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM15

UniProt ID: Q96T37

Entrez ID: 64783

Protein name: RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM15 in