DegronMD

Uniprot ID: Q96T37

Source protein: RNA-binding protein 15

Source gene: RBM15

Class: LIG_APCC_ABBAyCdc20_2

Location: 95:101

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9377

ASA_SCORE: 118.3714

COIL: 0.8896

CONS_SCORE: 0.3285

DSS_SCORE: 0.7191

HELIX: 0.057

FCONS_SCORE: 1.0767

RIG_SCORE: 0.6482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K87N	TCGA-AJ-A5DW	UCEC	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K87N	DO50075	UCEC	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S105N	TCGA-DK-A1AA	BLCA	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.6667
p.S105N	DO548	BLCA	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.6667
p.D101N	TCGA-EO-A22U	UCEC	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D101N	DO43755	UCEC	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.6932
p.E111D	TCGA-EO-A22X	UCEC	TCGA	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E111D	DO43907	UCEC	ICGC	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S103F	ACH-000969	Colon/Colorectal Cancer	CCLE	RRSLHLD	LIG_APCC_ABBAyCdc20_2	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T37	RNA-binding protein 15	LIG_APCC_ABBAyCdc20_2	95:101	RRSLHLD	APC,CDC20,FZR1	0.9377	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons