DegronMD - Q14123(PDE1C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R648H	TCGA-06-0649	GBM	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.25
p.E655K	TCGA-34-5232	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0556
p.E655K	TCGA-AA-3864	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0556
p.E655K	TCGA-DA-A1HY	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0556
p.V636A	TCGA-43-2576	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.S480Y	TCGA-53-7626	LUAD	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.S480Y	DO23774	LUAD	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.K633N	TCGA-AJ-A3EL	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation substituting flanking lysine	0.2222
p.K633N	SIDM00534	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation substituting flanking lysine	0.2222
p.K633N	ACH-000986	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	641:645	Mutation substituting flanking lysine	0.2222
p.K633N	HT-115	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation substituting flanking lysine	0.2222
p.N634K	TCGA-B5-A1MR	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1389
p.P474S	TCGA-D3-A8GI	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.6752
p.P474S	DO222702	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.6752
p.P474S	DO50284	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.6752
p.M482I	TCGA-D3-A8GO	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1111
p.M482I	TCGA-GN-A26C	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1111
p.M482I	DO37782	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1111
p.M482I	DO51242	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1111
p.V483D	TCGA-DA-A1IC	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.0833
p.V483D	DO37430	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.0833
p.G649E	TCGA-EE-A17Y	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.2222
p.P647L	TCGA-EE-A29E	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.2778
p.R464K	TCGA-EE-A29V	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2778
p.R464K	DO38006	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2778
p.D463G	TCGA-EO-A22R	UCEC	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.D463G	DO42713	UCEC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.E465K	TCGA-FR-A8YC	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.3056
p.E465K	DO50301	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.3056
p.R478Q	TCGA-FS-A1ZZ	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2222
p.R478Q	TCGA-W3-AA1W	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2222
p.R478Q	DO228017	SKCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2222
p.R478Q	DO37412	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2222
p.R478Q	DO51277	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2222
p.S652F	TCGA-FS-A4F5	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1389
p.G638R	TCGA-IQ-A61H	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.25
p.D477Y	TCGA-KQ-A41N	BLCA	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.D477Y	DO223588	BLCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.R640L	TCGA-QQ-A5VB	SARC	TCGA	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.3056
p.S632L	DO228471	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0833
p.S475L	DO1285	BRCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.3056
p.S475L	DO220857	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.3056
p.D477N	DO51208	BRCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.R467C	DO44295	CESC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.8301
p.R467C	DO45513	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.8301
p.T481P	DO6994	CLLE	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1389
p.L475R	DO222790	COCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.3056
p.K479T	DO233269	GACA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation substituting flanking lysine	0.3056
p.S468L	DO13863	GBM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7667
p.S468L	DO13462	GBM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7667
p.S468L	DO232224	PBCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7667
p.S468L	DO40884	UCEC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7667
p.S468L	DO41524	UCEC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7667
p.S468L	HEC-1	endometrium	COSMIC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7667
p.S468W	DO14426	HNSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7874
p.L470M	DO228206	LICA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.711
p.A484D	DO229031	LICA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation substituting flanking lysine	0.1667
p.D463E	DO229035	LICA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.C476R	DO231786	LINC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2778
p.Q465H	DO26590	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.3056
p.V483F	DO26473	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.0833
p.R480Q	DO45513	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.R480Q	DO222363	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.R480Q	DO37429	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.V483A	DO222554	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.0833
p.G464R	DO222710	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2778
p.S472N	DO50291	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.7069
p.T460N	DO51271	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.G464E	DO219481	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2778
p.K633T	SIDM01277	Esophageal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation substituting flanking lysine	0.2222
p.G649V	SIDM00683	Prostate Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.2222
p.G649V	ACH-000977	lymph node	CCLE	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.2222
p.G649V	LNCaP-Clone-FGC	prostate	COSMIC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.2222
p.V636L	SIDM00461	Acute Myeloid Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM01237	Hepatocellular Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00473	Oral Cavity Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00007	Other Solid Cancers	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM01178	Other Solid Cancers	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM01161	Other Sarcomas	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00142	Endometrial Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00819	Kidney Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00177	Melanoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00310	Mesothelioma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM00059	Ovarian Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM01759	Hodgkin's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM01580	Melanoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.V636L	SIDM01760	Rhabdomyosarcoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.T632S	SIDM00845	Burkitt's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0833
p.T632S	SIDM00032	Bladder Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0833
p.T632S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0833
p.E655D	SIDM00193	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0556
p.E655D	ACH-000779	Lung Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0556
p.E655D	ACH-000991	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0556
p.E655D	SNU-81	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.0556
p.N634D	SIDM01611	Endometrial Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1389
p.N634D	ACH-000996	Endometrial/Uterine Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1389
p.K479R	ACH-000885	Ovarian Cancer	CCLE	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation substituting flanking lysine	0.3056
p.K479R	TOV-21G	ovary	COSMIC	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation substituting flanking lysine	0.3056
p.R460T	ACH-000975	Lung Cancer	CCLE	RRSSLNSIS	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.A641V	CW-2	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation altering degron motif	0.5825
p.L650F	JHH-2	liver	COSMIC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.1944
p.R649H	HCC1419	breast	COSMIC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation rewiring degron network	0.2222
p.A641S	Raji	haematopoietic and lymphoid tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	641:645	Mutation altering degron motif	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE1C

UniProt ID: Q14123

Entrez ID: 5137

Protein name: Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE1C in