DegronMD

Uniprot ID: Q14123

Source protein: Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Source gene: PDE1C

Class: DEG_APCC_DBOX_1

Location: 466:474

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 96.1222

COIL: 0.8051

CONS_SCORE: 0.3523

DSS_SCORE: 0.6289

HELIX: 0.1653

FCONS_SCORE: 1.1418

RIG_SCORE: 0.6531

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S480Y	TCGA-53-7626	LUAD	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667
p.S480Y	DO23774	LUAD	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667
p.P474S	TCGA-D3-A8GI	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.6752
p.P474S	DO222702	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.6752
p.P474S	DO50284	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.6752
p.M482I	TCGA-D3-A8GO	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.1111
p.M482I	TCGA-GN-A26C	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.1111
p.M482I	DO37782	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1111
p.M482I	DO51242	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1111
p.V483D	TCGA-DA-A1IC	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.0833
p.V483D	DO37430	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.0833
p.R464K	TCGA-EE-A29V	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.2778
p.R464K	DO38006	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.2778
p.D463G	TCGA-EO-A22R	UCEC	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.25
p.D463G	DO42713	UCEC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.25
p.E465K	TCGA-FR-A8YC	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.E465K	DO50301	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.R478Q	TCGA-FS-A1ZZ	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.2222
p.R478Q	TCGA-W3-AA1W	SKCM	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.2222
p.R478Q	DO228017	SKCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.2222
p.R478Q	DO37412	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.2222
p.R478Q	DO51277	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.2222
p.D477Y	TCGA-KQ-A41N	BLCA	TCGA	RRSSLNSIS	DEG_APCC_DBOX_1	0.25
p.D477Y	DO223588	BLCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.25
p.S475L	DO1285	BRCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.S475L	DO220857	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.D477N	DO51208	BRCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.25
p.R467C	DO44295	CESC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.8301
p.R467C	DO45513	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.8301
p.T481P	DO6994	CLLE	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1389
p.L475R	DO222790	COCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.K479T	DO233269	GACA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.S468L	DO13863	GBM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7667
p.S468L	DO13462	GBM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7667
p.S468L	DO232224	PBCA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7667
p.S468L	DO40884	UCEC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7667
p.S468L	DO41524	UCEC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7667
p.S468L	HEC-1	endometrium	COSMIC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7667
p.S468W	DO14426	HNSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7874
p.L470M	DO228206	LICA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.711
p.A484D	DO229031	LICA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667
p.D463E	DO229035	LICA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.25
p.C476R	DO231786	LINC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.2778
p.Q465H	DO26590	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.V483F	DO26473	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.0833
p.R480Q	DO45513	LUSC	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667
p.R480Q	DO222363	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667
p.R480Q	DO37429	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667
p.V483A	DO222554	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.0833
p.G464R	DO222710	MELA	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.2778
p.S472N	DO50291	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.7069
p.T460N	DO51271	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667
p.G464E	DO219481	SKCM	ICGC	RRSSLNSIS	DEG_APCC_DBOX_1	0.2778
p.K479R	ACH-000885	Ovarian Cancer	CCLE	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.K479R	TOV-21G	ovary	COSMIC	RRSSLNSIS	DEG_APCC_DBOX_1	0.3056
p.R460T	ACH-000975	Lung Cancer	CCLE	RRSSLNSIS	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRSSLNSIS

Degron related mutations and impact score

Drug responses associated with PDE1C mutations

All proteins holding degron of RRSSLNSIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14123	Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	DEG_APCC_DBOX_1	466:474	RRSSLNSIS	APC,CDC20,FZR1	0.9963	More...