DegronMD

Uniprot ID: Q14123

Source protein: Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Source gene: PDE1C

Class: DEG_SPOP_SBC_1

Location: 641:645

E3 ligase: SPOP

DEGRON score: 0.9831

ASA_SCORE: 78.8

COIL: 0.914

CONS_SCORE: 0.1104

DSS_SCORE: 0.6657

HELIX: 0.0418

FCONS_SCORE: 0.9017

RIG_SCORE: 0.5612

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R648H	TCGA-06-0649	GBM	TCGA	APSTS	DEG_SPOP_SBC_1	0.25
p.E655K	TCGA-34-5232	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	0.0556
p.E655K	TCGA-AA-3864	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	0.0556
p.E655K	TCGA-DA-A1HY	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	0.0556
p.V636A	TCGA-43-2576	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	0.1944
p.K633N	TCGA-AJ-A3EL	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	0.2222
p.K633N	SIDM00534	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.2222
p.K633N	ACH-000986	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.2222
p.K633N	HT-115	large_intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	0.2222
p.N634K	TCGA-B5-A1MR	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	0.1389
p.G649E	TCGA-EE-A17Y	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	0.2222
p.P647L	TCGA-EE-A29E	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	0.2778
p.S652F	TCGA-FS-A4F5	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	0.1389
p.G638R	TCGA-IQ-A61H	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	0.25
p.R640L	TCGA-QQ-A5VB	SARC	TCGA	APSTS	DEG_SPOP_SBC_1	0.3056
p.S632L	DO228471	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	0.0833
p.K633T	SIDM01277	Esophageal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.2222
p.G649V	SIDM00683	Prostate Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.2222
p.G649V	ACH-000977	lymph_node	CCLE	APSTS	DEG_SPOP_SBC_1	0.2222
p.G649V	LNCaP-Clone-FGC	prostate	COSMIC	APSTS	DEG_SPOP_SBC_1	0.2222
p.V636L	SIDM00461	Acute Myeloid Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01237	Hepatocellular Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00473	Oral Cavity Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00007	Other Solid Cancers	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01178	Other Solid Cancers	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01161	Other Sarcomas	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00142	Endometrial Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00819	Kidney Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00177	Melanoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00310	Mesothelioma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00059	Ovarian Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01759	Hodgkin's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01580	Melanoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01760	Rhabdomyosarcoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.T632S	SIDM00845	Burkitt's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.0833
p.T632S	SIDM00032	Bladder Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.0833
p.T632S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.0833
p.E655D	SIDM00193	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.0556
p.E655D	ACH-000779	Lung Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.0556
p.E655D	ACH-000991	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.0556
p.E655D	SNU-81	large_intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	0.0556
p.N634D	SIDM01611	Endometrial Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1389
p.N634D	ACH-000996	Endometrial/Uterine Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.1389
p.A641V	CW-2	large_intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	0.5825
p.L650F	JHH-2	liver	COSMIC	APSTS	DEG_SPOP_SBC_1	0.1944
p.R649H	HCC1419	breast	COSMIC	APSTS	DEG_SPOP_SBC_1	0.2222
p.A641S	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	DEG_SPOP_SBC_1	2270:2274	APSTS	SPOP	0.9988	More...
O60721	Sodium/potassium/calcium exchanger 1	DEG_SPOP_SBC_1	374:378	APSTS	SPOP	0.895	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	760:764	APSTS	SPOP	0.9536	More...
O75962	Triple functional domain protein	DEG_SPOP_SBC_1	2330:2334	APSTS	SPOP	0.9832	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	282:286	APSTS	SPOP	0.9986	More...
P20333	Tumor necrosis factor receptor superfamily member 1B	DEG_SPOP_SBC_1	236:240	APSTS	SPOP	0.8766	More...
P23193	Transcription elongation factor A protein 1	DEG_SPOP_SBC_1	133:137	APSTS	SPOP	0.9964	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	26:30	APSTS	SPOP	0.9904	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	962:966	APSTS	SPOP	0.9991	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	762:766	APSTS	SPOP	0.8531	More...
Q14123	Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	DEG_SPOP_SBC_1	641:645	APSTS	SPOP	0.9831	More...
Q15007	Pre-mRNA-splicing regulator WTAP	DEG_SPOP_SBC_1	248:252	APSTS	SPOP	0.9316	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	108:112	APSTS	SPOP	0.9976	More...
Q66K74	Microtubule-associated protein 1S	DEG_SPOP_SBC_1	565:569	APSTS	SPOP	0.972	More...
Q6IQ49	Replication stress response regulator SDE2	DEG_SPOP_SBC_1	238:242	APSTS	SPOP	0.999	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2700:2704	APSTS	SPOP	0.9449	More...
Q86V42	Protein FAM124A	DEG_SPOP_SBC_1	500:504	APSTS	SPOP	0.9876	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	374:378	APSTS	SPOP	0.9854	More...
Q8NCP5	Zinc finger and BTB domain-containing protein 44	DEG_SPOP_SBC_1	381:385	APSTS	SPOP	0.9707	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5164:5168	APSTS	SPOP	0.9867	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_SPOP_SBC_1	460:464	APSTS	SPOP	0.8719	More...
Q96MG7	Non-structural maintenance of chromosomes element 3 homolog	DEG_SPOP_SBC_1	47:51	APSTS	SPOP	0.9985	More...
Q96N64	PWWP domain-containing protein 2A	DEG_SPOP_SBC_1	613:617	APSTS	SPOP	0.9195	More...
Q96T37	RNA-binding protein 15	DEG_SPOP_SBC_1	753:757	APSTS	SPOP	0.9492	More...
Q9H1K4	Mitochondrial glutamate carrier 2	DEG_SPOP_SBC_1	146:150	APSTS	SPOP	0.6475	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	573:577	APSTS	SPOP	0.9899	More...
Q9H8N7	Zinc finger protein 395	DEG_SPOP_SBC_1	64:68	APSTS	SPOP	0.9883	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	114:118	APSTS	SPOP	0.8965	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	1162:1166	APSTS	SPOP	0.9964	More...
P0C7U3	Probable palmitoyltransferase ZDHHC11B	DEG_SPOP_SBC_1	346:350	APSTS	SPOP	0.9986	More...
Q5FWE3	Proline-rich transmembrane protein 3	DEG_SPOP_SBC_1	411:415	APSTS	SPOP	0.9643	More...
Q8NCU7	C2 calcium-dependent domain-containing protein 4A	DEG_SPOP_SBC_1	226:230	APSTS	SPOP	0.999	More...
Q9BUT9	MAPK regulated corepressor interacting protein 2	DEG_SPOP_SBC_1	76:80	APSTS	SPOP	0.9973	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	85:89	APSTS	SPOP	0.9092	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9733	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9531	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1842:1846	APSTS	SPOP	0.9477	More...
Q9H8U3	AN1-type zinc finger protein 3	DEG_SPOP_SBC_1	49:53	APSTS	SPOP	0.8073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTS

Degron related mutations and impact score

Drug responses associated with PDE1C mutations

All proteins holding degron of APSTS