DegronMD

Uniprot ID: Q14123

Source protein: Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Source gene: PDE1C

Class: DEG_SPOP_SBC_1

Location: 641:645

E3 ligase: SPOP

DEGRON score: 0.9831

ASA_SCORE: 78.8

COIL: 0.914

CONS_SCORE: 0.1104

DSS_SCORE: 0.6657

HELIX: 0.0418

FCONS_SCORE: 0.9017

RIG_SCORE: 0.5612

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A641S	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	0.7588
p.A641V	CW-2	large_intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	0.5825
p.R640L	TCGA-QQ-A5VB	SARC	TCGA	APSTS	DEG_SPOP_SBC_1	0.3056
p.P647L	TCGA-EE-A29E	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	0.2778
p.R648H	TCGA-06-0649	GBM	TCGA	APSTS	DEG_SPOP_SBC_1	0.25
p.G638R	TCGA-IQ-A61H	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	0.25
p.K633N	TCGA-AJ-A3EL	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	0.2222
p.K633N	SIDM00534	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.2222
p.K633N	ACH-000986	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.2222
p.K633N	HT-115	large_intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	0.2222
p.G649E	TCGA-EE-A17Y	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	0.2222
p.K633T	SIDM01277	Esophageal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.2222
p.G649V	SIDM00683	Prostate Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.2222
p.G649V	ACH-000977	lymph_node	CCLE	APSTS	DEG_SPOP_SBC_1	0.2222
p.G649V	LNCaP-Clone-FGC	prostate	COSMIC	APSTS	DEG_SPOP_SBC_1	0.2222
p.R649H	HCC1419	breast	COSMIC	APSTS	DEG_SPOP_SBC_1	0.2222
p.V636A	TCGA-43-2576	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00461	Acute Myeloid Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01237	Hepatocellular Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00473	Oral Cavity Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00007	Other Solid Cancers	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01178	Other Solid Cancers	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944
p.V636L	SIDM01161	Other Sarcomas	GDSC	APSTS	DEG_SPOP_SBC_1	0.1944

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Drug responses associated with PDE1C mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of APSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	114:118	APSTS	SPOP	0.8965	More...
Q9H8U3	AN1-type zinc finger protein 3	DEG_SPOP_SBC_1	49:53	APSTS	SPOP	0.8073	More...
Q8NCU7	C2 calcium-dependent domain-containing protein 4A	DEG_SPOP_SBC_1	226:230	APSTS	SPOP	0.999	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	374:378	APSTS	SPOP	0.9854	More...
Q14123	Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	DEG_SPOP_SBC_1	641:645	APSTS	SPOP	0.9831	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_SPOP_SBC_1	460:464	APSTS	SPOP	0.8719	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	108:112	APSTS	SPOP	0.9976	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2700:2704	APSTS	SPOP	0.9449	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	573:577	APSTS	SPOP	0.9899	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9733	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9531	More...
Q9BUT9	MAPK regulated corepressor interacting protein 2	DEG_SPOP_SBC_1	76:80	APSTS	SPOP	0.9973	More...
Q66K74	Microtubule-associated protein 1S	DEG_SPOP_SBC_1	565:569	APSTS	SPOP	0.972	More...
Q9H1K4	Mitochondrial glutamate carrier 2	DEG_SPOP_SBC_1	146:150	APSTS	SPOP	0.6475	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5164:5168	APSTS	SPOP	0.9867	More...
Q96MG7	Non-structural maintenance of chromosomes element 3 homolog	DEG_SPOP_SBC_1	47:51	APSTS	SPOP	0.9985	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	26:30	APSTS	SPOP	0.9904	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	760:764	APSTS	SPOP	0.9536	More...
Q15007	Pre-mRNA-splicing regulator WTAP	DEG_SPOP_SBC_1	248:252	APSTS	SPOP	0.9316	More...
P0C7U3	Probable palmitoyltransferase ZDHHC11B	DEG_SPOP_SBC_1	346:350	APSTS	SPOP	0.9986	More...
Q5FWE3	Proline-rich transmembrane protein 3	DEG_SPOP_SBC_1	411:415	APSTS	SPOP	0.9643	More...
Q86V42	Protein FAM124A	DEG_SPOP_SBC_1	500:504	APSTS	SPOP	0.9876	More...
Q96N64	PWWP domain-containing protein 2A	DEG_SPOP_SBC_1	613:617	APSTS	SPOP	0.9195	More...
Q6IQ49	Replication stress response regulator SDE2	DEG_SPOP_SBC_1	238:242	APSTS	SPOP	0.999	More...
Q96T37	RNA-binding protein 15	DEG_SPOP_SBC_1	753:757	APSTS	SPOP	0.9492	More...

Showing 1 to 25 of 38 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTS

Degron related mutations and impact score

Drug responses associated with PDE1C mutations

All proteins holding degron of APSTS