DegronMD - Q6ZRS2(SRCAP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1115L	TCGA-05-4396	LUAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.0556
p.R1115L	TCGA-05-4396	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.R1115L	DO23838	LUAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.0556
p.R1115L	DO23838	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.G574V	TCGA-05-4410	LUAD	TCGA	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation altering degron motif	0.6421
p.G574V	DO25426	LUAD	ICGC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation altering degron motif	0.6421
p.P1111H	TCGA-06-5416	GBM	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.1667
p.P1111H	DO10880	GBM	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.1667
p.L578V	TCGA-13-0751	OV	TCGA	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.2778
p.L578V	TCGA-DS-A0VM	CESC	TCGA	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.2778
p.L578V	DO6258	CESC	ICGC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.2778
p.L578V	DO30650	OV	ICGC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.2778
p.V1133L	TCGA-13-2059	OV	TCGA	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.V1133L	TCGA-13-2059	OV	TCGA	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0556
p.V1133L	TCGA-13-2059	OV	TCGA	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.3056
p.V1133L	DO229035	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.V1133L	DO229035	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0556
p.V1133L	DO229035	LICA	ICGC	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.3056
p.V1133L	DO29890	OV	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.V1133L	DO29890	OV	ICGC	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0556
p.V1133L	DO29890	OV	ICGC	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.3056
p.V1309L	TCGA-37-4141	LUSC	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.1111
p.E1005Q	TCGA-50-5936	LUAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.0556
p.E1005Q	DO24237	LUAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.0556
p.P1762S	TCGA-50-6591	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.0556
p.S1774L	TCGA-5M-AAT4	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation altering degron motif	0.7667
p.S2814L	TCGA-77-7141	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation altering degron motif	0.7667
p.S1033L	TCGA-77-A5GB	LUSC	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.0556
p.S1033L	DO45439	LUSC	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.0556
p.R1007W	TCGA-80-5611	LUAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.R1007W	TCGA-AZ-4323	COAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.R1007W	TCGA-EE-A3J7	SKCM	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.R1007W	DO7886	COAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.R1007W	DO23822	LUAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.R1007W	DO48770	SKCM	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.R1098P	TCGA-86-8669	LUAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.3056
p.R1098P	DO25574	LUAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.3056
p.E2810K	TCGA-98-8021	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.2778
p.E2810K	DO27468	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.2778
p.Q1661E	TCGA-A6-2674	COAD	TCGA	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.3056
p.Q1661E	TCGA-C8-A274	BRCA	TCGA	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.3056
p.Q1594H	TCGA-AA-A010	COAD	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.2222
p.T577A	TCGA-AD-6964	COAD	TCGA	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation blocking phosphorylation signal	0.75
p.T577A	DO8360	COAD	ICGC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation blocking phosphorylation signal	0.75
p.S1641Y	TCGA-AG-A002	READ	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.712
p.P1134S	TCGA-AJ-A3EK	UCEC	TCGA	PPGY	ITCH	1134:1137	Mutation altering degron motif	0.6752
p.P1134S	DO41584	UCEC	ICGC	PPGY	ITCH	1134:1137	Mutation altering degron motif	0.6752
p.P1794A	TCGA-AL-3468	KIRP	TCGA	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation altering degron motif	0.6392
p.G45D	TCGA-AP-A051	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.G45D	DO42673	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.G45D	SIDM00534	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.G45D	ACH-000986	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.G45D	HT-115	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.A1588T	TCGA-AP-A059	UCEC	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.0556
p.A1588T	DO41361	UCEC	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.0556
p.T1640A	TCGA-AP-A1DK	UCEC	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.6028
p.T1640A	DO42033	UCEC	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.6028
p.A1802T	TCGA-AP-A1DV	UCEC	TCGA	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation rewiring degron network	0.2222
p.A1802T	DO37409	SKCM	ICGC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation rewiring degron network	0.2222
p.T25I	TCGA-AX-A2HD	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1389
p.T25I	DO42608	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1389
p.P1015T	TCGA-B3-3925	KIRP	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.5919
p.P1015T	DO20867	KIRP	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.5919
p.S1733Y	TCGA-B5-A11E	UCEC	TCGA	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.1944
p.S1733Y	TCGA-B5-A11E	UCEC	TCGA	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0556
p.T2819N	TCGA-B5-A1MX	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.25
p.A1591T	TCGA-B5-A3FA	UCEC	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1389
p.R1318Q	TCGA-B5-A3FC	UCEC	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation altering degron motif	0.7329
p.A1666V	TCGA-BG-A222	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.1667
p.A1666V	DO42977	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.1667
p.G2713D	TCGA-BG-A222	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.0833
p.S1290R	TCGA-BR-6452	STAD	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.1389
p.S1290R	DO38404	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.1389
p.T1132A	TCGA-CA-6717	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1667
p.T1132A	TCGA-CA-6717	COAD	TCGA	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.2778
p.T1132A	DO8264	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1667
p.T1132A	DO8264	COAD	ICGC	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.2778
p.P1102L	TCGA-CD-A48A	STAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation altering degron motif	0.7582
p.P1102L	DO47781	STAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation altering degron motif	0.7582
p.L1289I	TCGA-CG-4460	STAD	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.1667
p.L1289I	DO38427	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.1667
p.P1334L	TCGA-CG-5721	STAD	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.0833
p.P1334L	TCGA-D8-A1JB	BRCA	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.0833
p.S1281R	TCGA-CG-5733	STAD	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation altering degron motif	0.6316
p.S1281R	DO38551	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation altering degron motif	0.6316
p.A2699V	TCGA-CM-5861	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.3056
p.A2699V	DO7918	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.3056
p.E2227K	TCGA-CV-7242	HNSC	TCGA	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.2778
p.E2227K	TCGA-CV-7242	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1667
p.E2227K	TCGA-XF-AAMZ	BLCA	TCGA	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.2778
p.E2227K	TCGA-XF-AAMZ	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1667
p.E2227K	DO219051	BLCA	ICGC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.2778
p.E2227K	DO219051	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1667
p.E2227K	DO14974	HNSC	ICGC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.2778
p.E2227K	DO14974	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1667
p.P1023R	TCGA-D6-8569	HNSC	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.6401
p.P1023R	DO14454	HNSC	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.6401
p.S2710L	TCGA-D7-A6EY	STAD	TCGA	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.1667
p.S2710L	DO50118	STAD	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.1667
p.S1105F	TCGA-D9-A1JW	SKCM	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation altering degron motif	0.7982
p.S1105F	DO37786	SKCM	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation altering degron motif	0.7982
p.P2881S	TCGA-DK-A6B6	BLCA	TCGA	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.5641
p.P2881S	TCGA-EE-A2MR	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.5641
p.P2881S	DO48576	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.5641
p.P2881S	DO37819	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.5641
p.Q1261H	TCGA-E2-A14R	BRCA	TCGA	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.2778
p.Q1261H	TCGA-MN-A4N1	LUAD	TCGA	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.2778
p.Q1261H	DO3822	BRCA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.2778
p.Q1261H	DO45328	LUAD	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.2778
p.E1031Q	TCGA-E7-A85H	BLCA	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.E1031Q	DO219018	BLCA	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.P2881L	TCGA-EB-A3Y6	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.6471
p.P1712L	TCGA-EB-A41A	SKCM	TCGA	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.1389
p.P1712L	TCGA-EB-A41A	SKCM	TCGA	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.2222
p.P1712L	DO222843	MELA	ICGC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.1389
p.P1712L	DO222843	MELA	ICGC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.2222
p.P1712L	DO37429	SKCM	ICGC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.1389
p.P1712L	DO37429	SKCM	ICGC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.2222
p.G2807W	TCGA-EE-A181	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.1944
p.S1278L	TCGA-EE-A2A1	SKCM	TCGA	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation altering degron motif	0.6556
p.S1278L	DO38045	SKCM	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation altering degron motif	0.6556
p.S2220L	TCGA-EE-A2MR	SKCM	TCGA	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation altering degron motif	0.6556
p.S2220L	TCGA-EE-A2MR	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation altering degron motif	0.7667
p.S2882L	TCGA-EE-A3JI	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.7667
p.S2882L	DO47268	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.7667
p.K581N	TCGA-EO-A22X	UCEC	TCGA	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation substituting flanking lysine	0.3056
p.K581N	DO233899	GACA	ICGC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation substituting flanking lysine	0.3056
p.K581N	DO43907	UCEC	ICGC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation substituting flanking lysine	0.3056
p.R1115C	TCGA-EO-A22X	UCEC	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.0556
p.R1115C	TCGA-EO-A22X	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.R1115C	TCGA-YD-A9TA	SKCM	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.0556
p.R1115C	TCGA-YD-A9TA	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.R1115C	DO219503	SKCM	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.0556
p.R1115C	DO219503	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.R1115C	DO43907	UCEC	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.0556
p.R1115C	DO43907	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1389
p.P1535L	TCGA-ER-A19O	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.25
p.P1265L	TCGA-EY-A215	UCEC	TCGA	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation altering degron motif	0.6471
p.P1265L	DO42665	UCEC	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation altering degron motif	0.6471
p.V1427M	TCGA-EY-A215	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	1426:1430	Mutation altering degron motif	0.6097
p.G1639E	TCGA-F7-A624	HNSC	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.6087
p.G1639E	DO44440	HNSC	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.6087
p.L1525V	TCGA-GD-A3OP	BLCA	TCGA	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.25
p.Q253H	TCGA-GU-A767	BLCA	TCGA	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.3056
p.Q253H	DO51892	BLCA	ICGC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.3056
p.R1016Q	TCGA-HU-A4H8	STAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.7329
p.R1016Q	DO47869	STAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.7329
p.A2234S	TCGA-IB-7651	PAAD	TCGA	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.0833
p.R1318W	TCGA-LN-A49U	ESCA	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation altering degron motif	0.8634
p.R1332L	TCGA-NJ-A4YF	LUAD	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.1389
p.A1591V	TCGA-QQ-A8VF	SARC	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1389
p.A1591V	DO220258	SARC	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1389
p.D2211H	TCGA-VS-A9UZ	CESC	TCGA	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.2222
p.D2211H	TCGA-VS-A9UZ	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1667
p.P1121S	TCGA-W3-AA1V	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.3056
p.P1121S	DO51276	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.3056
p.P2881A	TCGA-XF-A9SM	BLCA	TCGA	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.6392
p.P1630S	TCGA-XF-A9T8	BLCA	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation rewiring degron network	0.2222
p.P1630S	TCGA-XF-A9T8	BLCA	TCGA	APSST	DEG_SPOP_SBC_1	1633:1637	Mutation rewiring degron network	0.25
p.P1111S	TCGA-YL-A8SJ	PRAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.1667
p.P1111S	DO51432	PRAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.1667
p.P1284L	DO48423	BLCA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.3056
p.P2819A	DO223597	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.25
p.S1125C	DO1076	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.7541
p.P1272L	DO4611	BRCA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.2778
p.P1272L	DO4611	BRCA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.2222
p.P1272L	DO38192	STAD	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.2778
p.P1272L	DO38192	STAD	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.2222
p.Q1599E	DO5675	BRCA	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation altering degron motif	0.6744
p.Q1599E	DO7819	COAD	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation altering degron motif	0.6744
p.I2892S	DO10244	COAD	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1111
p.S1712L	DO223702	COAD	ICGC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.1389
p.S1712L	DO223702	COAD	ICGC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.2222
p.R1792C	DO8786	COAD	ICGC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation altering degron motif	0.8301
p.R1792C	DO41235	UCEC	ICGC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation altering degron motif	0.8301
p.Q2707R	DO230326	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.25
p.Q2707R	DO228935	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.25
p.Q2707R	DO227802	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.25
p.Q2707R	DO51761	STAD	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.25
p.N2890T	DO230343	COCA	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1667
p.T1285M	DO227984	COCA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.2778
p.G45S	DO222600	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.G45S	DO45299	LIRI	ICGC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.S258N	DO222765	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.818
p.A1017V	DO222809	COCA	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.5825
p.T1787A	DO222842	COCA	ICGC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation rewiring degron network	0.2778
p.T1096I	DO222842	COCA	ICGC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.25
p.Q1636E	DO48242	ESCA	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.6744
p.Q1636E	DO48242	ESCA	ICGC	APSST	DEG_SPOP_SBC_1	1633:1637	Mutation altering degron motif	0.6744
p.S1797I	DO233784	GACA	ICGC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation altering degron motif	0.7341
p.G1737D	DO233882	GACA	ICGC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0833
p.R1778Q	DO233935	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.2778
p.P1485S	DO44437	HNSC	ICGC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation altering degron motif	0.6752
p.S2893P	DO219077	HNSC	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.0833
p.G1630A	DO18552	KIRC	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation rewiring degron network	0.2222
p.G1630A	DO18552	KIRC	ICGC	APSST	DEG_SPOP_SBC_1	1633:1637	Mutation rewiring degron network	0.25
p.P1636A	DO20839	KIRP	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.7503
p.P1636A	DO20839	KIRP	ICGC	APSST	DEG_SPOP_SBC_1	1633:1637	Mutation altering degron motif	0.7503
p.I2888F	DO228278	LICA	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation substituting flanking lysine	0.3333
p.V1773F	DO228555	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation altering degron motif	0.7068
p.V1773F	DO229037	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation altering degron motif	0.7068
p.S1270F	DO228946	LICA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation altering degron motif	0.7982
p.G1709V	DO228948	LICA	ICGC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0556
p.G1709V	DO228948	LICA	ICGC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.V2815L	DO228974	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation altering degron motif	0.6765
p.A2223S	DO229019	LICA	ICGC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation altering degron motif	0.7588
p.G26C	DO229019	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1667
p.V1262F	DO229022	LICA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.3056
p.E2208D	DO229035	LICA	ICGC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.1389
p.E2208D	DO229035	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.0833
p.A1285S	DO229045	LICA	ICGC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.2778
p.P1122L	DO229058	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.7582
p.G23R	DO50843	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.I2888V	DO50922	LICA	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation substituting flanking lysine	0.3333
p.A1330D	DO49657	LIHC	ICGC	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.1944
p.T1523N	DO23765	LUAD	ICGC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1944
p.R2235W	DO26250	LUAD	ICGC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.0556
p.P1478L	DO220912	MELA	ICGC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation altering degron motif	0.6471
p.S1661F	DO222413	MELA	ICGC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.3056
p.P1140S	DO222527	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.25
p.P1140S	DO222527	MELA	ICGC	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.25
p.P1140S	DO222753	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.25
p.P1140S	DO222753	MELA	ICGC	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.25
p.T1540A	DO50704	ORCA	ICGC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1111
p.T1540A	SIDM00616	Hepatocellular Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1111
p.T1540A	ACH-000476	Liver Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1111
p.T1540A	JHH-4	liver	COSMIC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1111
p.P1710L	DO49154	PACA	ICGC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0833
p.P1710L	DO49154	PACA	ICGC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1667
p.L246I	DO51962	PRAD	ICGC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.P1333S	DO228567	PRAD	ICGC	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.1111
p.L1768P	DO46921	RECA	ICGC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.2222
p.P573L	DO228017	SKCA	ICGC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation altering degron motif	0.7582
p.P2802T	DO37567	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.0556
p.P2802L	DO47253	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.0556
p.P1770L	DO50301	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.2778
p.G1446C	DO47374	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.P2819L	DO38081	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.25
p.P1473L	DO38063	SKCM	ICGC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.1944
p.P1634A	DO69151	THCA	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	1634:1641	Mutation altering degron motif	0.7503
p.P1634A	DO69151	THCA	ICGC	APSST	DEG_SPOP_SBC_1	1633:1637	Mutation altering degron motif	0.6392
p.V2702A	DO42384	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation altering degron motif	0.6936
p.A1529T	DO52402	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation altering degron motif	0.7139
p.P1595T	DO42977	UCEC	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.25
p.R1256Q	DO41871	UCEC	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.1389
p.R2703W	DO41871	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation altering degron motif	0.8634
p.R2703W	DO42472	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation altering degron motif	0.8634
p.A2883V	DO41235	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation altering degron motif	0.6936
p.Q1804P	SIDM02027	Colorectal Carcinoma	GDSC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation rewiring degron network	0.1667
p.T2205A	SIDM02026	Colorectal Carcinoma	GDSC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.0556
p.M24T	SIDM01951	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1111
p.R2875G	SIDM00373	Endometrial Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1944
p.R2875G	ACH-000974	Endometrial/Uterine Cancer	CCLE	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1944
p.R2875G	ACH-002026	Endometrial/Uterine Cancer	CCLE	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1944
p.R2875G	SNG-M	endometrium	COSMIC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1944
p.A1618V	SIDM00338	Acute Myeloid Leukemia	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1389
p.A1618V	SIDM00560	Gastric Carcinoma	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1389
p.A1618V	MKN7	stomach	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1389
p.A1618V	ME-1	haematopoietic and lymphoid tissue	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1389
p.G1522S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1667
p.G1522S	ACH-000995	Leukemia	CCLE	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1667
p.G1522S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1667
p.T1767M	SIDM01006	Plasma Cell Myeloma	GDSC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.1944
p.T1767M	SIDM00425	Ovarian Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.1944
p.S1468L	SIDM00371	Pancreatic Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM00157	Neuroblastoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM00569	Osteosarcoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM00687	Gastric Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM00245	Small Cell Lung Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM01210	Glioblastoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM00616	Hepatocellular Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM01412	Oral Cavity Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM01494	Glioblastoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM01321	Pancreatic Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SIDM01443	Gastric Carcinoma	GDSC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	KNS-81-FD	central nervous system	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	JHH-4	liver	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	KP-N-YS	autonomic ganglia	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	SUIT-2	pancreas	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	NY	bone	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	MS-1	lung	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	PC-3_[JPC-3]	lung	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.S1468L	KATOIII	stomach	COSMIC	PPLAPVVPA	DEG_SIAH_1	1478:1486	Mutation rewiring degron network	0.0556
p.P264S	SIDM00545	Melanoma	GDSC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1667
p.P264S	ACH-000987	Skin Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1667
p.P264S	Mewo	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1667
p.R1016W	SIDM00857	Melanoma	GDSC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.8634
p.R1016W	ACH-000572	Skin Cancer	CCLE	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.8634
p.R1016W	G-361	skin	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation altering degron motif	0.8634
p.E2230V	SIDM01261	Breast Carcinoma	GDSC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.1944
p.E2230V	SIDM01261	Breast Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.0833
p.E2230V	YMB-1-E	breast	COSMIC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.1944
p.E2230V	YMB-1-E	breast	COSMIC	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.0833
p.T1446I	SIDM00617	Hepatocellular Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	SIDM00350	Head and Neck Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	SIDM00567	Other Solid Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	SIDM00359	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	ACH-000565	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	ACH-000577	Liver Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	ACH-000776	Brain Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	ACH-001641	Head and Neck Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	RCM-1	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	JHH-2	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	ONS-76	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.T1446I	SAT	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.1111
p.R1025Q	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.2778
p.R1025Q	ACH-002272	Lymphoma	CCLE	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.2778
p.R1025Q	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.2778
p.G1522D	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1667
p.G1522D	ACH-002272	Lymphoma	CCLE	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1667
p.G1522D	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	1528:1532	Mutation rewiring degron network	0.1667
p.I1260V	SIDM00845	Burkitt's Lymphoma	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.25
p.I1260V	SIDM00461	Acute Myeloid Leukemia	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.25
p.I1260V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.25
p.I1260V	SIDM01519	Head and Neck Carcinoma	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.25
p.I1260V	ACH-000786	Lymphoma	CCLE	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.25
p.I1260V	Daudi	haematopoietic and lymphoid tissue	COSMIC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation rewiring degron network	0.25
p.L1664I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.2222
p.L1664I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.2222
p.C2809R	SIDM00654	Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.25
p.C2809R	ACH-000866	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.25
p.C2809R	NCI-H1048	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.25
p.P1108S	SIDM01136	Pancreatic Carcinoma	GDSC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.25
p.P1108S	ACH-000417	Pancreatic Cancer	CCLE	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.25
p.P1108S	PANC-08-13	pancreas	COSMIC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.25
p.P1669L	SIDM00465	Ovarian Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.0833
p.P1669L	SIDM00612	Glioma	GDSC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.0833
p.P1669L	KINGS-1	central nervous system	COSMIC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.0833
p.P1669L	OVMIU	ovary	COSMIC	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.0833
p.L266F	SIDM00803	Kidney Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.L266F	ACH-000411	Kidney Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.L266F	769-P	kidney	COSMIC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.T572I	SIDM00190	Melanoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation altering degron motif	0.8189
p.T572I	ACH-002097	Skin Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation altering degron motif	0.8189
p.T572I	CP66-MEL	skin	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation altering degron motif	0.8189
p.A1330E	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.1944
p.A1330E	ACH-000843	Lung Cancer	CCLE	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.1944
p.A1330E	HARA	lung	COSMIC	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation rewiring degron network	0.1944
p.G23S	SIDM00238	Ovarian Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.G23S	SIDM00360	Other Solid Cancers	GDSC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.G23S	OVK-18	ovary	COSMIC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.0833
p.A43T	SIDM01093	Cervical Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1389
p.A43T	ACH-000556	Cervical Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1389
p.A43T	SiHa	cervix	COSMIC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1389
p.A1424T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PVSST	DEG_SPOP_SBC_1	1426:1430	Mutation rewiring degron network	0.2778
p.A1424T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.0556
p.L1790S	SIDM00333	Endometrial Carcinoma	GDSC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation altering degron motif	0.6556
p.L1790S	ACH-000988	Endometrial/Uterine Cancer	CCLE	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation altering degron motif	0.6556
p.P1707T	SIDM01113	Other Sarcomas	GDSC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.P1707T	ACH-000939	Sarcoma	CCLE	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.P1707T	SK-UT-1	soft tissue	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.E563G	SIDM01045	Endometrial Carcinoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.1389
p.E563G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.1389
p.E563G	EN	endometrium	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.1389
p.S1421F	SIDM00487	Colorectal Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	1426:1430	Mutation rewiring degron network	0.1944
p.S1421F	ACH-000963	Colon/Colorectal Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	1426:1430	Mutation rewiring degron network	0.1944
p.S1421F	CCK-81	large intestine	COSMIC	PVSST	DEG_SPOP_SBC_1	1426:1430	Mutation rewiring degron network	0.1944
p.L1131P	SIDM00564	Ovarian Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1944
p.L1131P	SIDM00564	Ovarian Carcinoma	GDSC	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.25
p.L1131P	ACH-000527	Ovarian Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1944
p.L1131P	ACH-000527	Ovarian Cancer	CCLE	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.25
p.L1131P	OVISE	ovary	COSMIC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1944
p.L1131P	OVISE	ovary	COSMIC	PPGY	ITCH	1134:1137	Mutation rewiring degron network	0.25
p.P1602A	SIDM01157	Other Solid Cancers	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation altering degron motif	0.6392
p.P1602A	SW954	vulva	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation altering degron motif	0.6392
p.P1292S	SIDM00140	Melanoma	GDSC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.0833
p.P1292S	ACH-000968	Skin Cancer	CCLE	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.0833
p.P1292S	COLO-792	skin	COSMIC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.0833
p.G1709R	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0556
p.G1709R	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.G1709R	ACH-000904	Lung Cancer	CCLE	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0556
p.G1709R	ACH-000904	Lung Cancer	CCLE	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.G1709R	ACH-001362	Lung Cancer	CCLE	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0556
p.G1709R	ACH-001362	Lung Cancer	CCLE	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.G1709R	NCI-H1770	lung	COSMIC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0556
p.G1709R	NCI-H1770	lung	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.G267C	SIDM00794	Other Solid Cancers	GDSC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.G267C	ACH-001442	Skin Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.G267C	A388	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0833
p.T1715S	SIDM00943	Pancreatic Carcinoma	GDSC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.2222
p.T1715S	SIDM00943	Pancreatic Carcinoma	GDSC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.3056
p.T1715S	ACH-000107	Pancreatic Cancer	CCLE	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.2222
p.T1715S	ACH-000107	Pancreatic Cancer	CCLE	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.3056
p.T1715S	Capan-2	pancreas	COSMIC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.2222
p.T1715S	Capan-2	pancreas	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.3056
p.G1095W	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.2222
p.G1095W	ACH-000727	Lung Cancer	CCLE	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.2222
p.G1095W	NCI-H2066	lung	COSMIC	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.2222
p.G579D	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.25
p.G579D	ACH-002171	Lung Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.25
p.G579D	NCI-H250	lung	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.25
p.T1156I	SIDM00503	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0833
p.T1156I	ACH-000633	Gastric Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0833
p.T1156I	FU97	stomach	COSMIC	AATTT	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0833
p.M1590I	SIDM01372	Pancreatic Carcinoma	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1111
p.M1590I	ACH-000266	Pancreatic Cancer	CCLE	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation rewiring degron network	0.1111
p.P1434S	SIDM01629	Melanoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation altering degron motif	0.6752
p.P1434S	ACH-000404	Skin Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation altering degron motif	0.6752
p.G569R	SIDM01735	Biliary Tract Carcinoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.3056
p.G569R	ACH-000808	Bile Duct Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.3056
p.A1633S	SIDM01617	Endometrial Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	1633:1637	Mutation altering degron motif	0.7588
p.A1633S	ACH-000994	Endometrial/Uterine Cancer	CCLE	APSST	DEG_SPOP_SBC_1	1633:1637	Mutation altering degron motif	0.7588
p.S1290G	SIDM01594	Breast Carcinoma	GDSC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.1389
p.V1009E	SIDM00163	Biliary Tract Carcinoma	GDSC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1667
p.S34L	SIDM01587	Bladder Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.7667
p.S34L	ACH-000753	Bladder Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.7667
p.A1765D	SIDM01619	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.1389
p.A1765D	ACH-000984	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.1389
p.V1324I	ACH-000635	Ovarian Cancer	CCLE	PRDGLTPVP	DEG_APCC_DBOX_1	1317:1325	Mutation altering degron motif	0.5965
p.T1662I	ACH-000811	Ovarian Cancer	CCLE	APSST	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.2778
p.A1765T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.1389
p.P2226L	ACH-001063	Ovarian Cancer	CCLE	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.3056
p.P2226L	ACH-001063	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1944
p.R1098W	ACH-001518	Endometrial/Uterine Cancer	CCLE	PPTPTLS	DEG_SCF_FBW7_1	1099:1105	Mutation rewiring degron network	0.3056
p.D2872H	ACH-001853	Bile Duct Cancer	CCLE	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1111
p.P1448T	SK-UT-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation rewiring degron network	0.0556
p.A2893V	SNU-C5	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.0833
p.P1736Q	JHOS-4	ovary	COSMIC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.1111
p.R2811W	D-542MG	central nervous system	COSMIC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.3056
p.T1606A	NCI-H1648	lung	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	1598:1611	Mutation altering degron motif	0.7139
p.Q571H	HCT-15	large intestine	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation altering degron motif	0.7582
p.L1029V	NCI-SNU-1	stomach	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1667
p.L1029V	MRK-nu-1	breast	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1667
p.L2807M	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	2812:2816	Mutation rewiring degron network	0.1944
p.S2703F	Sarc9371	bone	COSMIC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation altering degron motif	0.7982
p.D1708E	Daudi	haematopoietic and lymphoid tissue	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1111
p.A259V	MZ7-mel	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.3056
p.R2879H	22RV1	prostate	COSMIC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.3056
p.T1788M	MDA-MB-175-VII	breast	COSMIC	TLSPAPVPTL	DEG_COP1_1	1789:1798	Mutation rewiring degron network	0.3056
p.V1031A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	1015:1023	Mutation rewiring degron network	0.1111
p.R561H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	570:576	Mutation rewiring degron network	0.0833
p.P2226S	Mewo	skin	COSMIC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.3056
p.P2226S	Mewo	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1944
p.A2893G	MFH-ino	soft tissue	COSMIC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.0833
p.P1737S	BE-13	haematopoietic and lymphoid tissue	COSMIC	TPASSLVPTP	DEG_COP1_1	1719:1728	Mutation rewiring degron network	0.0833
p.T1281A	JHH-4	liver	COSMIC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation altering degron motif	0.7139
p.P2228A	CHP-134	autonomic ganglia	COSMIC	EEPSSSSVPSA	DEG_COP1_1	2215:2225	Mutation rewiring degron network	0.25
p.P2228A	CHP-134	autonomic ganglia	COSMIC	PSSSS	DEG_SPOP_SBC_1	2217:2221	Mutation rewiring degron network	0.1389
p.V1119L	ASH-3	thyroid	COSMIC	PGSSS	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.25
p.P2870S	SW684	soft tissue	COSMIC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.0556
p.G1263D	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation altering degron motif	0.7198
p.R1770H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	1772:1776	Mutation rewiring degron network	0.2778
p.S2714L	MDST8	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	2700:2704	Mutation rewiring degron network	0.0556
p.P2890H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	2880:2884	Mutation rewiring degron network	0.1667
p.V1289L	SK-MEL-24	skin	COSMIC	PSSTPSTT	DEG_SCF_FBW7_1	1276:1283	Mutation rewiring degron network	0.1667
p.G1263S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VAPTPGPT	DEG_SCF_FBW7_1	1263:1270	Mutation altering degron motif	0.6993
p.G1434V	NCI-H2087	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	1434:1438	Mutation altering degron motif	0.7532

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRCAP

UniProt ID: Q6ZRS2

Entrez ID: 10847

Protein name: Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRCAP in