DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_COP1_1

Location: 1789:1798

E3 ligase: COP1

DEGRON score: 0.96

ASA_SCORE: 78.68

COIL: 0.8508

CONS_SCORE: 0.1666

DSS_SCORE: 0.3597

HELIX: 0.0167

FCONS_SCORE: 0.9187

RIG_SCORE: 0.7014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1794A	TCGA-AL-3468	KIRP	TCGA	TLSPAPVPTL	DEG_COP1_1	0.6392
p.A1802T	TCGA-AP-A1DV	UCEC	TCGA	TLSPAPVPTL	DEG_COP1_1	0.2222
p.A1802T	DO37409	SKCM	ICGC	TLSPAPVPTL	DEG_COP1_1	0.2222
p.R1792C	DO8786	COAD	ICGC	TLSPAPVPTL	DEG_COP1_1	0.8301
p.R1792C	DO41235	UCEC	ICGC	TLSPAPVPTL	DEG_COP1_1	0.8301
p.T1787A	DO222842	COCA	ICGC	TLSPAPVPTL	DEG_COP1_1	0.2778
p.S1797I	DO233784	GACA	ICGC	TLSPAPVPTL	DEG_COP1_1	0.7341
p.Q1804P	SIDM02027	Colorectal Carcinoma	GDSC	TLSPAPVPTL	DEG_COP1_1	0.1667
p.L1790S	SIDM00333	Endometrial Carcinoma	GDSC	TLSPAPVPTL	DEG_COP1_1	0.6556
p.L1790S	ACH-000988	Endometrial/Uterine Cancer	CCLE	TLSPAPVPTL	DEG_COP1_1	0.6556
p.T1788M	MDA-MB-175-VII	breast	COSMIC	TLSPAPVPTL	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_COP1_1	1789:1798	TLSPAPVPTL	COP1	0.96	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons