DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_SCF_FBW7_1

Location: 1634:1641

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 78.95

COIL: 0.9388

CONS_SCORE: 0.1657

DSS_SCORE: 0.5065

HELIX: 0.0279

FCONS_SCORE: 0.988

RIG_SCORE: 0.5744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1641Y	TCGA-AG-A002	READ	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	0.712
p.T1640A	TCGA-AP-A1DK	UCEC	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	0.6028
p.T1640A	DO42033	UCEC	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	0.6028
p.G1639E	TCGA-F7-A624	HNSC	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	0.6087
p.G1639E	DO44440	HNSC	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	0.6087
p.P1630S	TCGA-XF-A9T8	BLCA	TCGA	PSSTPGTS	DEG_SCF_FBW7_1	0.2222
p.Q1636E	DO48242	ESCA	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	0.6744
p.G1630A	DO18552	KIRC	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	0.2222
p.P1636A	DO20839	KIRP	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	0.7503
p.P1634A	DO69151	THCA	ICGC	PSSTPGTS	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_SCF_FBW7_1	1634:1641	PSSTPGTS	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons