DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_COP1_1

Location: 1719:1728

E3 ligase: COP1

DEGRON score: 0.607

ASA_SCORE: 82.16

COIL: 0.8697

CONS_SCORE: 0.1707

DSS_SCORE: 0.5553

HELIX: 0.032

FCONS_SCORE: 0.9983

RIG_SCORE: 0.6806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1733Y	TCGA-B5-A11E	UCEC	TCGA	TPASSLVPTP	DEG_COP1_1	0.1944
p.P1712L	TCGA-EB-A41A	SKCM	TCGA	TPASSLVPTP	DEG_COP1_1	0.1389
p.P1712L	DO222843	MELA	ICGC	TPASSLVPTP	DEG_COP1_1	0.1389
p.P1712L	DO37429	SKCM	ICGC	TPASSLVPTP	DEG_COP1_1	0.1389
p.S1712L	DO223702	COAD	ICGC	TPASSLVPTP	DEG_COP1_1	0.1389
p.G1737D	DO233882	GACA	ICGC	TPASSLVPTP	DEG_COP1_1	0.0833
p.G1709V	DO228948	LICA	ICGC	TPASSLVPTP	DEG_COP1_1	0.0556
p.P1710L	DO49154	PACA	ICGC	TPASSLVPTP	DEG_COP1_1	0.0833
p.G1709R	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	TPASSLVPTP	DEG_COP1_1	0.0556
p.G1709R	ACH-000904	Lung Cancer	CCLE	TPASSLVPTP	DEG_COP1_1	0.0556
p.G1709R	ACH-001362	Lung Cancer	CCLE	TPASSLVPTP	DEG_COP1_1	0.0556
p.G1709R	NCI-H1770	lung	COSMIC	TPASSLVPTP	DEG_COP1_1	0.0556
p.T1715S	SIDM00943	Pancreatic Carcinoma	GDSC	TPASSLVPTP	DEG_COP1_1	0.2222
p.T1715S	ACH-000107	Pancreatic Cancer	CCLE	TPASSLVPTP	DEG_COP1_1	0.2222
p.T1715S	Capan-2	pancreas	COSMIC	TPASSLVPTP	DEG_COP1_1	0.2222
p.P1736Q	JHOS-4	ovary	COSMIC	TPASSLVPTP	DEG_COP1_1	0.1111
p.P1737S	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	TPASSLVPTP	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_COP1_1	1719:1728	TPASSLVPTP	COP1	0.607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons