DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_APCC_DBOX_1

Location: 1015:1023

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9201

ASA_SCORE: 83.6667

COIL: 0.9131

CONS_SCORE: 0.3167

DSS_SCORE: 0.5509

HELIX: 0.012

FCONS_SCORE: 0.9743

RIG_SCORE: 0.6267

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1005Q	TCGA-50-5936	LUAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.0556
p.E1005Q	DO24237	LUAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.0556
p.S1033L	TCGA-77-A5GB	LUSC	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.0556
p.S1033L	DO45439	LUSC	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.0556
p.R1007W	TCGA-80-5611	LUAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.R1007W	TCGA-AZ-4323	COAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.R1007W	TCGA-EE-A3J7	SKCM	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.R1007W	DO7886	COAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.R1007W	DO23822	LUAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.R1007W	DO48770	SKCM	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.P1015T	TCGA-B3-3925	KIRP	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.5919
p.P1015T	DO20867	KIRP	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.5919
p.P1023R	TCGA-D6-8569	HNSC	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.6401
p.P1023R	DO14454	HNSC	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.6401
p.E1031Q	TCGA-E7-A85H	BLCA	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.E1031Q	DO219018	BLCA	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111
p.R1016Q	TCGA-HU-A4H8	STAD	TCGA	PRAPLGPVP	DEG_APCC_DBOX_1	0.7329
p.R1016Q	DO47869	STAD	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.7329
p.A1017V	DO222809	COCA	ICGC	PRAPLGPVP	DEG_APCC_DBOX_1	0.5825
p.R1016W	SIDM00857	Melanoma	GDSC	PRAPLGPVP	DEG_APCC_DBOX_1	0.8634
p.R1016W	ACH-000572	Skin Cancer	CCLE	PRAPLGPVP	DEG_APCC_DBOX_1	0.8634
p.R1016W	G-361	skin	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	0.8634
p.R1025Q	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRAPLGPVP	DEG_APCC_DBOX_1	0.2778
p.R1025Q	ACH-002272	Lymphoma	CCLE	PRAPLGPVP	DEG_APCC_DBOX_1	0.2778
p.R1025Q	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	0.2778
p.V1009E	SIDM00163	Biliary Tract Carcinoma	GDSC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1667
p.L1029V	NCI-SNU-1	stomach	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1667
p.L1029V	MRK-nu-1	breast	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1667
p.V1031A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PRAPLGPVP	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAPLGPVP

Degron related mutations and impact score

Drug responses associated with SRCAP mutations

All proteins holding degron of PRAPLGPVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_APCC_DBOX_1	1015:1023	PRAPLGPVP	APC,CDC20,FZR1	0.9201	More...