DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_SCF_FBW7_1

Location: 1099:1105

E3 ligase: FBXW7

DEGRON score: 0.7901

ASA_SCORE: 84.9286

COIL: 0.9333

CONS_SCORE: 0.2043

DSS_SCORE: 0.6786

HELIX: 0.0163

FCONS_SCORE: 0.9439

RIG_SCORE: 0.6001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1115L	TCGA-05-4396	LUAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.0556
p.R1115L	DO23838	LUAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.0556
p.P1111H	TCGA-06-5416	GBM	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.1667
p.P1111H	DO10880	GBM	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.1667
p.R1098P	TCGA-86-8669	LUAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.3056
p.R1098P	DO25574	LUAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.3056
p.P1102L	TCGA-CD-A48A	STAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.7582
p.P1102L	DO47781	STAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.7582
p.S1105F	TCGA-D9-A1JW	SKCM	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.7982
p.S1105F	DO37786	SKCM	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.7982
p.R1115C	TCGA-EO-A22X	UCEC	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.0556
p.R1115C	TCGA-YD-A9TA	SKCM	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.0556
p.R1115C	DO219503	SKCM	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.0556
p.R1115C	DO43907	UCEC	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.0556
p.P1111S	TCGA-YL-A8SJ	PRAD	TCGA	PPTPTLS	DEG_SCF_FBW7_1	0.1667
p.P1111S	DO51432	PRAD	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.1667
p.T1096I	DO222842	COCA	ICGC	PPTPTLS	DEG_SCF_FBW7_1	0.25
p.P1108S	SIDM01136	Pancreatic Carcinoma	GDSC	PPTPTLS	DEG_SCF_FBW7_1	0.25
p.P1108S	ACH-000417	Pancreatic Cancer	CCLE	PPTPTLS	DEG_SCF_FBW7_1	0.25
p.P1108S	PANC-08-13	pancreas	COSMIC	PPTPTLS	DEG_SCF_FBW7_1	0.25
p.G1095W	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PPTPTLS	DEG_SCF_FBW7_1	0.2222
p.G1095W	ACH-000727	Lung Cancer	CCLE	PPTPTLS	DEG_SCF_FBW7_1	0.2222
p.G1095W	NCI-H2066	lung	COSMIC	PPTPTLS	DEG_SCF_FBW7_1	0.2222
p.R1098W	ACH-001518	Endometrial/Uterine Cancer	CCLE	PPTPTLS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_SCF_FBW7_1	1099:1105	PPTPTLS	FBXW7	0.7901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons