DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_ODPH_VHL_1

Location: 1598:1611

E3 ligase: VHL

DEGRON score: 0.8733

ASA_SCORE: 83.2214

COIL: 0.9188

CONS_SCORE: 0.1663

DSS_SCORE: 0.3662

HELIX: 0.0143

FCONS_SCORE: 0.9522

RIG_SCORE: 0.66

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1594H	TCGA-AA-A010	COAD	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.2222
p.A1588T	TCGA-AP-A059	UCEC	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.0556
p.A1588T	DO41361	UCEC	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.0556
p.A1591T	TCGA-B5-A3FA	UCEC	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1389
p.A1591V	TCGA-QQ-A8VF	SARC	TCGA	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1389
p.A1591V	DO220258	SARC	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1389
p.Q1599E	DO5675	BRCA	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.6744
p.Q1599E	DO7819	COAD	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.6744
p.P1595T	DO42977	UCEC	ICGC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.25
p.A1618V	SIDM00338	Acute Myeloid Leukemia	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1389
p.A1618V	SIDM00560	Gastric Carcinoma	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1389
p.A1618V	MKN7	stomach	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1389
p.A1618V	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1389
p.P1602A	SIDM01157	Other Solid Cancers	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.6392
p.P1602A	SW954	vulva	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.6392
p.M1590I	SIDM01372	Pancreatic Carcinoma	GDSC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1111
p.M1590I	ACH-000266	Pancreatic Cancer	CCLE	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.1111
p.T1606A	NCI-H1648	lung	COSMIC	LAPSPAPPLAPLPV	DEG_ODPH_VHL_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_ODPH_VHL_1	1598:1611	LAPSPAPPLAPLPV	VHL	0.8733	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons