DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_APCC_DBOX_1

Location: 1317:1325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9702

ASA_SCORE: 81.0444

COIL: 0.8761

CONS_SCORE: 0.3641

DSS_SCORE: 0.5286

HELIX: 0.0302

FCONS_SCORE: 0.9674

RIG_SCORE: 0.6729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1309L	TCGA-37-4141	LUSC	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	0.1111
p.R1318Q	TCGA-B5-A3FC	UCEC	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	0.7329
p.P1334L	TCGA-CG-5721	STAD	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	0.0833
p.P1334L	TCGA-D8-A1JB	BRCA	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	0.0833
p.R1318W	TCGA-LN-A49U	ESCA	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	0.8634
p.R1332L	TCGA-NJ-A4YF	LUAD	TCGA	PRDGLTPVP	DEG_APCC_DBOX_1	0.1389
p.A1330D	DO49657	LIHC	ICGC	PRDGLTPVP	DEG_APCC_DBOX_1	0.1944
p.P1333S	DO228567	PRAD	ICGC	PRDGLTPVP	DEG_APCC_DBOX_1	0.1111
p.A1330E	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PRDGLTPVP	DEG_APCC_DBOX_1	0.1944
p.A1330E	ACH-000843	Lung Cancer	CCLE	PRDGLTPVP	DEG_APCC_DBOX_1	0.1944
p.A1330E	HARA	lung	COSMIC	PRDGLTPVP	DEG_APCC_DBOX_1	0.1944
p.V1324I	ACH-000635	Ovarian Cancer	CCLE	PRDGLTPVP	DEG_APCC_DBOX_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_APCC_DBOX_1	1317:1325	PRDGLTPVP	APC,CDC20,FZR1	0.9702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons