DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_SCF_FBW7_1

Location: 1716:1723

E3 ligase: FBXW7

DEGRON score: 0.9643

ASA_SCORE: 81.0875

COIL: 0.8336

CONS_SCORE: 0.1713

DSS_SCORE: 0.6014

HELIX: 0.0418

FCONS_SCORE: 1.0054

RIG_SCORE: 0.6853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1733Y	TCGA-B5-A11E	UCEC	TCGA	LSLTPASS	DEG_SCF_FBW7_1	0.0556
p.P1712L	TCGA-EB-A41A	SKCM	TCGA	LSLTPASS	DEG_SCF_FBW7_1	0.2222
p.P1712L	DO222843	MELA	ICGC	LSLTPASS	DEG_SCF_FBW7_1	0.2222
p.P1712L	DO37429	SKCM	ICGC	LSLTPASS	DEG_SCF_FBW7_1	0.2222
p.S1712L	DO223702	COAD	ICGC	LSLTPASS	DEG_SCF_FBW7_1	0.2222
p.G1709V	DO228948	LICA	ICGC	LSLTPASS	DEG_SCF_FBW7_1	0.1389
p.P1710L	DO49154	PACA	ICGC	LSLTPASS	DEG_SCF_FBW7_1	0.1667
p.P1707T	SIDM01113	Other Sarcomas	GDSC	LSLTPASS	DEG_SCF_FBW7_1	0.0833
p.P1707T	ACH-000939	Sarcoma	CCLE	LSLTPASS	DEG_SCF_FBW7_1	0.0833
p.P1707T	SK-UT-1	soft_tissue	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	0.0833
p.G1709R	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LSLTPASS	DEG_SCF_FBW7_1	0.1389
p.G1709R	ACH-000904	Lung Cancer	CCLE	LSLTPASS	DEG_SCF_FBW7_1	0.1389
p.G1709R	ACH-001362	Lung Cancer	CCLE	LSLTPASS	DEG_SCF_FBW7_1	0.1389
p.G1709R	NCI-H1770	lung	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	0.1389
p.T1715S	SIDM00943	Pancreatic Carcinoma	GDSC	LSLTPASS	DEG_SCF_FBW7_1	0.3056
p.T1715S	ACH-000107	Pancreatic Cancer	CCLE	LSLTPASS	DEG_SCF_FBW7_1	0.3056
p.T1715S	Capan-2	pancreas	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	0.3056
p.D1708E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LSLTPASS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_SCF_FBW7_1	1716:1723	LSLTPASS	FBXW7	0.9643	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons