DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_SCF_FBW7_1

Location: 1263:1270

E3 ligase: FBXW7

DEGRON score: 0.9314

ASA_SCORE: 91.5625

COIL: 0.9706

CONS_SCORE: 0.2434

DSS_SCORE: 0.4249

HELIX: 0.0078

FCONS_SCORE: 0.8429

RIG_SCORE: 0.6246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1261H	TCGA-E2-A14R	BRCA	TCGA	VAPTPGPT	DEG_SCF_FBW7_1	0.2778
p.Q1261H	TCGA-MN-A4N1	LUAD	TCGA	VAPTPGPT	DEG_SCF_FBW7_1	0.2778
p.Q1261H	DO3822	BRCA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.2778
p.Q1261H	DO45328	LUAD	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.2778
p.P1265L	TCGA-EY-A215	UCEC	TCGA	VAPTPGPT	DEG_SCF_FBW7_1	0.6471
p.P1265L	DO42665	UCEC	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.6471
p.P1272L	DO4611	BRCA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.2778
p.P1272L	DO38192	STAD	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.2778
p.S1270F	DO228946	LICA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.7982
p.V1262F	DO229022	LICA	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.3056
p.R1256Q	DO41871	UCEC	ICGC	VAPTPGPT	DEG_SCF_FBW7_1	0.1389
p.I1260V	SIDM00845	Burkitt's Lymphoma	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	0.25
p.I1260V	SIDM00461	Acute Myeloid Leukemia	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	0.25
p.I1260V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	0.25
p.I1260V	SIDM01519	Head and Neck Carcinoma	GDSC	VAPTPGPT	DEG_SCF_FBW7_1	0.25
p.I1260V	ACH-000786	Lymphoma	CCLE	VAPTPGPT	DEG_SCF_FBW7_1	0.25
p.I1260V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VAPTPGPT	DEG_SCF_FBW7_1	0.25
p.G1263D	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VAPTPGPT	DEG_SCF_FBW7_1	0.7198
p.G1263S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VAPTPGPT	DEG_SCF_FBW7_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_SCF_FBW7_1	1263:1270	VAPTPGPT	FBXW7	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons