DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPTPGPT
Uniprot ID:
Q6ZRS2
Source protein:
Helicase SRCAP
Source gene:
SRCAP
Class:
DEG_SCF_FBW7_1
Location:
570:576
E3 ligase:
FBXW7
DEGRON score:
0.9169
ASA_SCORE:
92.5571
COIL:
0.9631
CONS_SCORE:
0.3165
DSS_SCORE:
0.8305
HELIX:
0.0181
FCONS_SCORE:
0.9217
RIG_SCORE:
0.5269
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T572I
SIDM00190
Melanoma
GDSC
PPTPGPT
DEG_SCF_FBW7_1
0.8189
p.T572I
ACH-002097
Skin Cancer
CCLE
PPTPGPT
DEG_SCF_FBW7_1
0.8189
p.T572I
CP66-MEL
skin
COSMIC
PPTPGPT
DEG_SCF_FBW7_1
0.8189
p.P573L
DO228017
SKCA
ICGC
PPTPGPT
DEG_SCF_FBW7_1
0.7582
p.Q571H
HCT-15
large_intestine
COSMIC
PPTPGPT
DEG_SCF_FBW7_1
0.7582
p.T577A
TCGA-AD-6964
COAD
TCGA
PPTPGPT
DEG_SCF_FBW7_1
0.75
p.T577A
DO8360
COAD
ICGC
PPTPGPT
DEG_SCF_FBW7_1
0.75
p.G574V
TCGA-05-4410
LUAD
TCGA
PPTPGPT
DEG_SCF_FBW7_1
0.6421
p.G574V
DO25426
LUAD
ICGC
PPTPGPT
DEG_SCF_FBW7_1
0.6421
p.K581N
TCGA-EO-A22X
UCEC
TCGA
PPTPGPT
DEG_SCF_FBW7_1
0.3056
p.K581N
DO233899
GACA
ICGC
PPTPGPT
DEG_SCF_FBW7_1
0.3056
p.K581N
DO43907
UCEC
ICGC
PPTPGPT
DEG_SCF_FBW7_1
0.3056
p.G569R
SIDM01735
Biliary Tract Carcinoma
GDSC
PPTPGPT
DEG_SCF_FBW7_1
0.3056
p.G569R
ACH-000808
Bile Duct Cancer
CCLE
PPTPGPT
DEG_SCF_FBW7_1
0.3056
p.L578V
TCGA-13-0751
OV
TCGA
PPTPGPT
DEG_SCF_FBW7_1
0.2778
p.L578V
TCGA-DS-A0VM
CESC
TCGA
PPTPGPT
DEG_SCF_FBW7_1
0.2778
p.L578V
DO6258
CESC
ICGC
PPTPGPT
DEG_SCF_FBW7_1
0.2778
p.L578V
DO30650
OV
ICGC
PPTPGPT
DEG_SCF_FBW7_1
0.2778
p.G579D
SIDM00721
Small Cell Lung Carcinoma
GDSC
PPTPGPT
DEG_SCF_FBW7_1
0.25
p.G579D
ACH-002171
Lung Cancer
CCLE
PPTPGPT
DEG_SCF_FBW7_1
0.25
p.G579D
NCI-H250
lung
COSMIC
PPTPGPT
DEG_SCF_FBW7_1
0.25
p.E563G
SIDM01045
Endometrial Carcinoma
GDSC
PPTPGPT
DEG_SCF_FBW7_1
0.1389
p.E563G
ACH-000978
Endometrial/Uterine Cancer
CCLE
PPTPGPT
DEG_SCF_FBW7_1
0.1389
p.E563G
EN
endometrium
COSMIC
PPTPGPT
DEG_SCF_FBW7_1
0.1389
p.R561H
CTV-1
haematopoietic_and_lymphoid_tissue
COSMIC
PPTPGPT
DEG_SCF_FBW7_1
0.0833
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Drug responses associated with SRCAP mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PPTPGPT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZRS2
Helicase SRCAP
DEG_SCF_FBW7_1
570:576
PPTPGPT
FBXW7
0.9169
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