DegronMD

Uniprot ID: Q6ZRS2

Source protein: Helicase SRCAP

Source gene: SRCAP

Class: DEG_SCF_FBW7_1

Location: 570:576

E3 ligase: FBXW7

DEGRON score: 0.9169

ASA_SCORE: 92.5571

COIL: 0.9631

CONS_SCORE: 0.3165

DSS_SCORE: 0.8305

HELIX: 0.0181

FCONS_SCORE: 0.9217

RIG_SCORE: 0.5269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G574V	TCGA-05-4410	LUAD	TCGA	PPTPGPT	DEG_SCF_FBW7_1	0.6421
p.G574V	DO25426	LUAD	ICGC	PPTPGPT	DEG_SCF_FBW7_1	0.6421
p.L578V	TCGA-13-0751	OV	TCGA	PPTPGPT	DEG_SCF_FBW7_1	0.2778
p.L578V	TCGA-DS-A0VM	CESC	TCGA	PPTPGPT	DEG_SCF_FBW7_1	0.2778
p.L578V	DO6258	CESC	ICGC	PPTPGPT	DEG_SCF_FBW7_1	0.2778
p.L578V	DO30650	OV	ICGC	PPTPGPT	DEG_SCF_FBW7_1	0.2778
p.T577A	TCGA-AD-6964	COAD	TCGA	PPTPGPT	DEG_SCF_FBW7_1	0.75
p.T577A	DO8360	COAD	ICGC	PPTPGPT	DEG_SCF_FBW7_1	0.75
p.K581N	TCGA-EO-A22X	UCEC	TCGA	PPTPGPT	DEG_SCF_FBW7_1	0.3056
p.K581N	DO233899	GACA	ICGC	PPTPGPT	DEG_SCF_FBW7_1	0.3056
p.K581N	DO43907	UCEC	ICGC	PPTPGPT	DEG_SCF_FBW7_1	0.3056
p.P573L	DO228017	SKCA	ICGC	PPTPGPT	DEG_SCF_FBW7_1	0.7582
p.T572I	SIDM00190	Melanoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	0.8189
p.T572I	ACH-002097	Skin Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	0.8189
p.T572I	CP66-MEL	skin	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	0.8189
p.E563G	SIDM01045	Endometrial Carcinoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	0.1389
p.E563G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	0.1389
p.E563G	EN	endometrium	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	0.1389
p.G579D	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	0.25
p.G579D	ACH-002171	Lung Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	0.25
p.G579D	NCI-H250	lung	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	0.25
p.G569R	SIDM01735	Biliary Tract Carcinoma	GDSC	PPTPGPT	DEG_SCF_FBW7_1	0.3056
p.G569R	ACH-000808	Bile Duct Cancer	CCLE	PPTPGPT	DEG_SCF_FBW7_1	0.3056
p.Q571H	HCT-15	large_intestine	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	0.7582
p.R561H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPGPT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRS2	Helicase SRCAP	DEG_SCF_FBW7_1	570:576	PPTPGPT	FBXW7	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPGPT

Degron related mutations and impact score

Drug responses associated with SRCAP mutations

All proteins holding degron of PPTPGPT